The Continuous-Flow Synthesis of Styrenes Using Ethylene in a Palladium-Catalysed Heck Cross-Coupling Reaction

被引：58

作者：

Bourne, Samuel L. ^{[1
]}

Koos, Peter ^{[1
]}

O'Brien, Matthew ^{[1
]}

Martin, Benjamin ^{[2
]}

Schenkel, Berthold ^{[2
]}

Baxendale, Ian R. ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

[2] Novartis Pharma AG, Chem & Analyt Dev, CH-4057 Basel, Switzerland

来源：

SYNLETT | 2011年 / 18期

基金：

英国工程与自然科学研究理事会;

关键词：

vinylation; membrane; flow; ethylene; styrene; ORGANIC-SYNTHESIS; MICROREACTOR; CHEMISTRY; ARYL; ARYLATION; ECONOMY; HALIDES;

D O I：

10.1055/s-0031-1289291

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a palladium-catalysed ethylene Heck reaction for the vinylation of aryl iodides using a tube-in-tube gas-liquid reactor. The flow process afforded various styrenes in short reaction times, employing moderate ethylene pressure.

引用

页码：2643 / 2647

页数：5

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