Synthesis of acetal protected building blocks using flow chemistry with flow IR analysis: preparation of butane-2,3-diacetal tartrates

被引:61
作者
Carter, Catherine F. [1 ]
Baxendale, Ian R. [1 ]
O'Brien, Matthew [1 ]
Pavey, John B. J. [2 ]
Ley, Steven V. [1 ]
机构
[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England
[2] AstraZeneca, Loughborough LE11 5RH, Leics, England
基金
英国工程与自然科学研究理事会;
关键词
ANNONACEOUS ACETOGENIN; MULTISTEP SYNTHESIS; ORGANIC-SYNTHESIS; NATURAL-PRODUCT; DERIVATIVES; REACTOR; UTILITY; ACID;
D O I
10.1039/b917289k
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The syntheses of butane-2,3-diacetal protected tartrate derivatives are described using continuous flow processing techniques with in-line purification and I.R. analytical protocols.
引用
收藏
页码:4594 / 4597
页数:4
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