Short communication:: Trypanosoma cruzi lineage I in endomyocardial biopsy from a north-eastern Brazilian patient at end-stage chronic chagasic cardiomyopathy

被引：36

作者：

Teixeira, MMG

daSilva, FM

Marcili, A

Umezawa, ES

Shikanai-Yasuda, MA

Cunha-Neto, E

Kalil, J

Stolf, N

Stolf, AMS

机构：

[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, BR-05508900 Sao Paulo, Brazil

[2] Univ Sao Paulo, Inst Med Trop Sao Paulo, BR-05508900 Sao Paulo, Brazil

[3] Univ Sao Paulo, Fac Med, Inst Coracao, Lab Imunol, BR-05508900 Sao Paulo, Brazil

[4] Univ Sao Paulo, Fac Med, Inst Coracao, Div Cirurgia, BR-05508900 Sao Paulo, Brazil

来源：

TROPICAL MEDICINE & INTERNATIONAL HEALTH | 2006年 / 11卷 / 03期

关键词：

Trypanosoma cruzi; Chagas disease; genetic typing; cardiomyopathy; endomyocardial biopsy; T. cruzi lineages;

D O I：

10.1111/j.1365-3156.2006.01575.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Trypanosoma cruzi, the agent of Chagas disease, is genetically classified into two major evolutionary lineages, T. cruzi I and T. cruzi II. In Southern American Cone countries it is T cruzi II which causes most cases of severe chronic Chagas disease. Contrary to this, we isolated T. cruzi I nested in endomyocardial biopsies of a chronic chagasic patient with end-stage heart failure. Our finding should alert clinicians to the possibility of severe Chagas disease in all regions where T. cruzi circulates, regardless of its lineage.

引用

页码：294 / 298

页数：5

共 16 条

[1] Chronic Chagas' disease cardiomyopathy patients display an increased IFN-γ response to Trypanosoma cruzi infection [J].