Trypanosoma cruzi clonal diversity and the epidemiology of Chagas' disease

被引：89

作者：

Buscaglia, CA

Di Noia, JM

机构：

[1] NYU, Sch Med, Dept Pathol, Michael Heidelberger Div Immunol, New York, NY 10016 USA

[2] MRC, Mol Biol Lab, PNAC Unit, Cambridge CB2 2QH, England

来源：

MICROBES AND INFECTION | 2003年 / 5卷 / 05期

关键词：

Trypanosoma cruzi; Chagas' disease; clonality; epidemiology; TSSA;

D O I：

10.1016/S1286-4579(03)00050-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chagas' disease is caused by the protozoan Trypanosoma cruzi and it has a variable clinical outcome. The basis for this variability relies in part on the complexity of the parasite population consisting of multiple clones displaying distinct biological properties. A major current challenge is to correlate parasite genetic variability with pathogenesis. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

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收藏

页码：419 / 427

页数：9

相关论文

共 47 条

[1] Differential tissue distribution of diverse clones of Trypanosoma cruzi in infected mice [J].

Andrade, LO ;

Machado, CRS ;

Chiari, E ;

Pena, SDJ ;

Macedo, AM .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1999, 100 (02) :163-172

[2] Different behavior of two Trypanosoma cruzi major clones:: Transmission and circulation in young Bolivian patients [J].

Brenière, SF ;

Bosseno, MF ;

Telleria, J ;

Bastrenta, B ;

Yacsik, N ;

Noireau, F ;

Alcazar, JL ;

Barnabé, C ;

Wincker, P ;

Tibayrenc, M .

EXPERIMENTAL PARASITOLOGY, 1998, 89 (03) :285-295

[3] The evolution of two Trypanosoma cruzi subgroups inferred from rRNA genes can be correlated with the interchange of American mammalian faunas in the Cenozoic and has implications to pathogenicity and host specificity [J].

Briones, MRS ;

Souto, RP ;

Stolf, BS ;

Zingales, B .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1999, 104 (02) :219-232

[4] Identification of six Trypanosoma cruzi lineages by sequence-characterised amplified region markers [J].

Brisse, S ;

Dujardin, JC ;

Tibayrenc, M .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2000, 111 (01) :95-105

[5] Identification of six Trypanosoma cruzi phylogenetic lineages by random amplified polymorphic DNA and multilocus enzyme electrophoresis [J].

Brisse, S ;

Barnabé, C ;

Tibayrenc, M .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2000, 30 (01) :35-44

[6] Structural variation in the glycoinositolphospholipids of different strains of Trypanosoma cruzi [J].

Carreira, JC ;

Jones, C ;

Wait, R ;

Previato, JO ;

MendoncaPreviato, L .

GLYCOCONJUGATE JOURNAL, 1996, 13 (06) :955-966

[7] ASCORBATE VARIATION AND DEHYDROASCORBATE REDUCTASE-ACTIVITY IN TRYPANOSOMA-CRUZI EPIMASTIGOTES AND TRYPOMASTIGOTES [J].

CLARK, D ;

ALBRECHT, M ;

AREVALO, J .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1994, 66 (01) :143-145

[8] Emerging Chagas disease in Amazonian Brazil [J].

Coura, JR ;

Junqueira, ACV ;

Fernandes, O ;

Valente, SAS ;

Miles, MA .

TRENDS IN PARASITOLOGY, 2002, 18 (04) :171-176

[9] Trypanosoma cruzi:: Compared vectorial transmissibility of three major clonal genotypes by Triatoma infestans [J].

de Lana, M ;

Pinto, AD ;

Barnabé, C ;

Quesney, V ;

Noël, S ;

Tibayrenc, M .

EXPERIMENTAL PARASITOLOGY, 1998, 90 (01) :20-25

[10] The Trypanosoma cruzi mucin family is transcribed from hundreds of genes having hypervariable regions [J].

Di Noia, JM ;

D'Orso, I ;

Åslund, L ;

Sánchez, DO ;

Frasch, ACC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (18) :10843-10850

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