Buprenorphine pharmacokinetics: Relative bioavailability of sublingual tablet and liquid formulations

被引：89

作者：

Nath, RP ^{[1
]}

Upton, RA ^{[1
]}

Everhart, T ^{[1
]}

Cheung, P ^{[1
]}

Shwonek, P ^{[1
]}

Jones, RT ^{[1
]}

Mendelson, JE ^{[1
]}

机构：

[1] Univ Calif San Francisco, Drug Dependence Res Ctr, Langley Porter Psychiat Inst, San Francisco, CA 94143 USA

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 1999年 / 39卷 / 06期

关键词：

D O I：

10.1177/00912709922008236

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Buprenorphine is an effective new treatment for opiate dependence. This study compared the bioavailability of buprenorphine from a tablet to that from a reference solution. Six men experienced with, but not dependent on, opiates (DSM-III-R) were each administered 7.7 mg of buprenorphine in liquid form and 8 mg in tablet form 1 week apart in a balanced crossover design. plasma levels were measured by electron capture capillary gas chromatography (GC), and concentration-time curves were constructed. Pharmacokinetic data were analyzed by analysis of variance. The bioavailability from the tablet was approximately 50% that from the liquid and was not affected by saliva pH. Lower bioavailability from the tablet may be due to slow dissolution. (C) 1999 the American College of Clinical Pharmacology.

引用

页码：619 / 623

页数：5

共 16 条

[11] SUBSTITUTION PHARMACOTHERAPIES FOR OPIOID ADDICTION - FROM METHADONE TO LAAM AND BUPRENORPHINE [J].