Platelet function analyzer (PFA)-100® closure time in the evaluation of platelet disorders and platelet function

被引:300
作者
Hayward, CPM
Harrison, P
Cattaneo, M
Ortel, TL
Rao, AK
机构
[1] McMaster Univ, Med Ctr, Hamilton Hlth Sci Corp, Hamilton, ON L8N 3Z5, Canada
[2] Hamilton Reg Lab Med Program, Hamilton, ON, Canada
[3] Churchill Hosp, Oxford Haemophilia Ctr, Oxford OX3 7LJ, England
[4] Churchill Hosp, Thrombosis Unit, Oxford OX3 7LJ, England
[5] Univ Milan, DMCO, Osped San Paolo, Unita Ematol & Trombois, Milan, Italy
[6] Duke Univ, Med Ctr, Durham, NC USA
[7] Temple Univ, Sol Sherry Thrombosis Res Ctr, Sch Med, Philadelphia, PA 19140 USA
关键词
D O I
10.1111/j.1538-7836.2006.01771.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Closure time (CT), measured by platelet function analyzer (PFA-100((R))) device, is now available to the clinical laboratory as a possible alternative or supplement to the bleeding time test. Aim: On behalf of the Platelet Physiology Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis (ISTH-SSC), a working Group was formed to review and make recommendations on the use of the PFA-100 CT in the evaluation of platelet function within the clinical laboratory. Methods: The Medline database was searched to review the published information on the PFA-100 CT in the evaluation of platelet disorders and platelet function. This information, and expert opinion, was used to prepare a report and generate consensus recommendations. Results: Although the PFA-100 CT is abnormal in some forms of platelet disorders, the test does not have sufficient sensitivity or specificity to be used as a screening tool for platelet disorders. A role of the PFA-100 CT in therapeutic monitoring of platelet function remains to be established. Conclusions: The PFA-100 closure time should be considered optional in the evaluation of platelet disorders and function, and its use in therapeutic monitoring of platelet function is currently best restricted to research studies and prospective clinical trials.
引用
收藏
页码:312 / 319
页数:8
相关论文
共 94 条
[41]   Performance of the platelet function analyser PFA-100® in testing abnormalities of primary haemostasis [J].
Harrison, P ;
Robinson, MSC ;
Mackie, IJ ;
Joseph, J ;
McDonald, SJ ;
Liesner, R ;
Savidge, GF ;
Pasi, J ;
Machin, SJ .
BLOOD COAGULATION & FIBRINOLYSIS, 1999, 10 (01) :25-31
[42]   Comparison of four commercial citrate blood collection systems for platelet function analysis by the PFA-100(TM) system [J].
Heilmann, EJ ;
Kundu, SK ;
Sio, R ;
Garcia, C ;
Gomez, R ;
Christie, DJ .
THROMBOSIS RESEARCH, 1997, 87 (01) :159-164
[43]   Paroxetine decreases platelet serotonin storage and platelet function in human beings [J].
Hergovich, N ;
Aigner, M ;
Eichler, HG ;
Entlicher, J ;
Drucker, C ;
Jilma, B .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2000, 68 (04) :435-442
[44]   Use ct the PFA-100™ apparatus to assess platelet function in patients undergoing PTCA during and after infusion of cE3 Fab in the presence of other antiplatelet agents [J].
Hézard, N ;
Metz, D ;
Nazeyrollas, P ;
Droulle, C ;
Elaerts, J ;
Potron, G ;
Nguyen, P .
THROMBOSIS AND HAEMOSTASIS, 2000, 83 (04) :540-544
[45]   Monitoring of aspirin (ASA) pharmacodynamics with the platelet function analyzer PFA-100® [J].
Homoncik, M ;
Jilma, B ;
Hergovich, N ;
Stohlawetz, P ;
Panzer, S ;
Speiser, W .
THROMBOSIS AND HAEMOSTASIS, 2000, 83 (02) :316-321
[46]   The effects of perioperatively administered colloids and crystalloids on primary platelet-mediated hemostasis and clot formation [J].
Innerhofer, P ;
Fries, D ;
Margreiter, J ;
Klingler, A ;
Kühbacher, G ;
Wachter, B ;
Oswald, E ;
Salner, E ;
Frischhut, B ;
Schobersberger, W .
ANESTHESIA AND ANALGESIA, 2002, 95 (04) :858-865
[47]   Evaluation of primary hemostasis in neonates with a new in vitro platelet function analyzer [J].
Israels, SJ ;
Cheang, T ;
McMillan-Ward, EM ;
Cheang, M .
JOURNAL OF PEDIATRICS, 2001, 138 (01) :116-119
[48]  
Jilma B, 2003, STROKE, V34, P854
[49]  
Jilma B, 2001, AM J CARDIOL, V88, P1348
[50]   Platelet function analyzer (PFA-100): A tool to quantify congenital or acquired platelet dysfunction [J].
Jilma, B .
JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2001, 138 (03) :152-163