Role of calcium during Toxoplasma gondii invasion and egress

被引：63

作者：

Arrizabalaga, G ^{[1
]}

Boothroyd, JC ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2004年 / 34卷 / 03期

关键词：

toxoplasma; calcium; invasion; egress; ethanol; ionophore;

D O I：

10.1016/j.ijpara.2003.11.017

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Calcium is a ubiquitous signalling molecule involved in a large number of cellular processes in eukaryotic cells. In the obligate intracellular parasite, Toxoplasma gondii, for example, a rise in calcium concentration is associated with significant morphological changes, secretion of proteins involved in host cell invasion and rapid egress from the host cell. Recent findings indicate that calcium released from the parasite's intracellular pools is necessary and sufficient to induce some of the events critical for invasion and egress. In addition, ethanol, a powerful inducer of invasion-related events, is shown here to also induce rapid egress from the host cell, indicating that a common mechanism for calcium release might be involved during both invasion and egress. (C) 2004 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：361 / 368

页数：8

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