Rhodium-Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α-Branched Products

被引：217

作者：

Chan, Louis K. M. ^{[1
]}

Poole, Darren L. ^{[1
]}

Shen, Di ^{[1
]}

Healy, Mark P. ^{[1
]}

Donohoe, Timothy J. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 03期

基金：

英国工程与自然科学研究理事会;

关键词：

homogeneous catalysis; hydrogen borrowing; ketones; methanol; TRANSITION-METAL-COMPLEXES; C BOND FORMATION; BORROWING HYDROGEN; PRIMARY ALCOHOLS; CARBONYL ADDITION; ALKYLATION; OXIDATION; ACTIVATION; ARYLACETONITRILES; MONOALKYLATION;

D O I：

10.1002/anie.201307950

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The rhodium-catalyzed methylation of ketones has been accomplished using methanol as the methylating agent and the hydrogen-borrowing method. The sequence is notable for the relatively low temperatures that are required and for the ability of the reaction system to form alpha-branched products with ease. Doubly alkylated ketones can be prepared from methyl ketones and two different alcohols by using a sequential one-pot iridium- and rhodium-catalyzed process.

引用

页码：761 / 765

页数：5

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