An emerging role for Ptdlns(4,5)P2-mediated signalling in human disease

被引：56

作者：

Halstead, JR

Jalink, K

Divecha, N

机构：

[1] Netherlands Canc Inst, Dept Cellular Biochem, NL-1066 CX Amsterdam, Netherlands

[2] Netherlands Canc Inst, Dept Cell Biol, NL-1066 CX Amsterdam, Netherlands

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 12期

关键词：

D O I：

10.1016/j.tips.2005.10.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Although an established regulator of many cellular functions, the phosphoinositide phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P-2] appears to have evaded the attention of drug-discovery companies. An increasing number of reports have identified potential links between PtdIns(4,5)P-2-mediated signalling pathways and the aetiology of many human diseases. Here, we review current knowledge of the regulation and function of PtdIns(4,5)P-2 and discuss how aberrant PtdIns(4,5)P-2-mediated signalling might contribute to human pathologies such as cardiac failure, bipolar disorder, channelopathies and the genetic disorder Lowe syndrome.

引用

收藏

页码：654 / 660

页数：7

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