CD4+ T-cell depletion in HIV infection:: Are we closer to understanding the cause?

被引：357

作者：

Grossman, Z ^{[1
]}

Meier-Schellersheim, M

Sousa, AE

Victorino, RMM

Paul, WE

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel

[2] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

[3] Fac Med Lisbon, Inst Mol Med, Lisbon, Portugal

来源：

NATURE MEDICINE | 2002年 / 8卷 / 04期

关键词：

D O I：

10.1038/nm0402-319

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Is CD4(+) cell depletion due to rapid elimination by HIV and failure of the immune system to replace these cells at the required rate? Increasing evidence suggests that this is not the case, and that infection-induced immune activation drives both viral replication and CD4(+) cell depletion.

引用

页码：319 / 323

页数：5

共 36 条

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