Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome

被引:314
作者
Munakata, J
Naliboff, B
Harraf, F
Kodner, A
Lembo, T
Chang, L
Silverman, DHS
Mayer, EA
机构
[1] UNIV CALIF LOS ANGELES, DEPT MED, CURE DIGEST DIS RES CTR, NEUROENTER BIOL GRP, LOS ANGELES, CA 90073 USA
[2] UNIV CALIF LOS ANGELES, DEPT PHYSIOL, W LOS ANGELES VET AFFAIRS MED CTR, LOS ANGELES, CA 90073 USA
[3] UNIV CALIF LOS ANGELES, DEPT PSYCHIAT, W LOS ANGELES VET AFFAIRS MED CTR, LOS ANGELES, CA 90073 USA
关键词
D O I
10.1016/S0016-5085(97)70219-1
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: Only a fraction of patients with irritable bowel syndrome (IBS) show hypersensitivity to rectal distention, The current study sought to determine if repetitive high-pressure stimulation of sigmoid mechanoreceptors modulates perception of rectal pain and discomfort. Methods: In 14 patients with IBS and 11 healthy controls, perception thresholds for discomfort and pain during rectal sensory tracking and verbal descriptor ratings of the perceived intensity of a rectal tonic stimulus were obtained before and after repetitive high-pressure mechanical sigmoid stimulation, Gastrointestinal and psychological symptoms were assessed by questionnaires, Results: Despite heterogeneity in baseline rectal sensitivity in patients with IBS, after sigmoid stimulation, 100% of patients, regardless of baseline sensitivity, developed rectal hyperalgesia manifested by at least two of the following three criteria: lowered thresholds for pain and discomfort and increased viscerosomatic referral and lower abdominal discomfort outlasting the experimental stimulation. This pattern of responses was not observed in any of the healthy controls, Conclusions: In patients with IBS, repetitive stimulation of sigmoid splanchnic afferents results in the development of central sensitization manifested as hyperalgesia and increased viscerosomatic referral during rectal distention and as spontaneous rectosigmoid hyperalgesia in the absence of applied stimuli, Repetitive sigmoid contractions may induce rectosigmoid hyperalgesia in patients with IBS.
引用
收藏
页码:55 / 63
页数:9
相关论文
共 31 条
  • [11] HANDWERKER HO, 1992, SYMP PAIN R, P107
  • [12] LOCAL SECRETION OF CORTICOTROPIN-RELEASING HORMONE BY ENTEROCHROMAFFIN CELLS IN HUMAN COLON
    KAWAHITO, Y
    SANO, H
    KAWATA, M
    YURI, K
    MUKAI, S
    YAMAMURA, Y
    KATO, H
    CHROUSOS, GP
    WILDER, RL
    KONDO, M
    [J]. GASTROENTEROLOGY, 1994, 106 (04) : 859 - 865
  • [13] Kirk R.E., 2012, EXPT DESIGN PROCEDUR, V4th
  • [14] EVIDENCE FOR THE HYPERSENSITIVITY OF LUMBAR SPLANCHNIC AFFERENTS IN IRRITABLE-BOWEL-SYNDROME
    LEMBO, T
    MUNAKATA, J
    MERTZ, H
    NIAZI, N
    KODNER, A
    NIKAS, V
    MAYER, EA
    [J]. GASTROENTEROLOGY, 1994, 107 (06) : 1686 - 1696
  • [15] THE SENSITIVE AND REACTIVE GUT
    MAYER, EA
    [J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1994, 6 (06) : 470 - 477
  • [16] MAYER EA, 1995, VISCERAL PAIN PROGR, V2, P429
  • [17] INTESTINAL MOTILITY IN IRRITABLE-BOWEL-SYNDROME - IS IBS A MOTILITY DISORDER .2. MOTILITY OF THE SMALL-BOWEL, ESOPHAGUS, STOMACH, AND GALLBLADDER
    MCKEE, DP
    QUIGLEY, EMM
    [J]. DIGESTIVE DISEASES AND SCIENCES, 1993, 38 (10) : 1773 - 1782
  • [18] INTESTINAL MOTILITY IN IRRITABLE-BOWEL-SYNDROME - IS IBS A MOTILITY DISORDER .1. DEFINITION OF IBS AND COLONIC MOTILITY
    MCKEE, DP
    QUIGLEY, EMM
    [J]. DIGESTIVE DISEASES AND SCIENCES, 1993, 38 (10) : 1761 - 1772
  • [19] ALTERED RECTAL PERCEPTION IS A BIOLOGICAL MARKER OF PATIENTS WITH IRRITABLE-BOWEL-SYNDROME
    MERTZ, H
    NALIBOFF, B
    MUNAKATA, J
    NIAZI, N
    MAYER, EA
    [J]. GASTROENTEROLOGY, 1995, 109 (01) : 40 - 52
  • [20] NALIBOFF B, 1995, GASTROENTEROLOGY, V108, pA656