Biotransformation of terpenes from Stemodia maritima by Aspergillus niger ATCC 9142

被引：28

作者：

Chen, ARM ^{[1
]}

Reese, PB ^{[1
]}

机构：

[1] Univ W Indies, Dept Chem, Kingston 7, Jamaica

来源：

PHYTOCHEMISTRY | 2002年 / 59卷 / 01期

关键词：

Aspergillus niger ATCC 9142; biotransformation; stemodane; stemarane; diterpene; Stemodia maritima; hydroxylation;

D O I：

10.1016/S0031-9422(01)00355-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Incubation of stemodin (1) in cultures of Aspergillus niger ATCC 9142 resulted in the production of 2alpha,3beta 13,18-trihydroxystemodane (2), 2alpha,7beta,13-trihydroxystemodane (3) and 2alpha,13,16beta-trihydroxystemodane (4), while stemodinone (5) afforded 13,18-dihydroxystemodan-2-one (6) and 13,16beta-dihydroxystemodan-2-one (7). Four novel metabolites were obtained from the bioconversion of stemarin (8) by the fungus, namely 18-hydroxystemaran-19-oic acid (9), 7beta,18-dihydroxystemaran-19-oic acid (10), 7alpha,18.19-trihydroxystemarane (11) and 1beta-hydroxystemaran-19-oic acid (12). 19-N,N-Dimethylcarbamoxy-13-hydroxystemarane (13) was also transformed to afford 19-N,N-dimethylcarbamoxy-13,17,18-trihydroxystemarane (14). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：57 / 62

页数：6

共 22 条

[1] STUDIES ON POLYNUCLEOTIDES .102. USE OF AROMATIC ISOCYANATES FOR SELECTIVE BLOCKING OF TERMINAL 3'-HYDROXYL GROUP IN PROTECTED DEOXYRIBOOLIGONUCLEOTIDES [J].