DNA condensation

被引：1034

作者：

Bloomfield, VA

机构：

[1] Department of Biochemistry, University of Minnesota, St. Paul

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1996年 / 6卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(96)80052-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent progress in our understanding of DNA condensation includes the observation of the collapse of single DNA molecules, greater insights into the intermolecular forces driving condensation, the recognition of helix-structure perturbation in condensed DNA, and the increasing recognition of the likely biological consequences of condensation. DNA condensed with cationic liposomes is an efficient agent for the transfection of eukaryotic cells, with considerable potential interest for gene therapy.

引用

收藏

页码：334 / 341

页数：8

相关论文

共 73 条

[21] BINDING OF DNA TO LIPOSOMES CONTAINING DIFFERENT DERIVATIVES OF SPHINGOSINE [J].

KOIV, A ;

KINNUNEN, PKJ .

CHEMISTRY AND PHYSICS OF LIPIDS, 1994, 72 (01) :77-86

[22] DIFFERENTIAL SCANNING CALORIMETRY STUDY ON THE BINDING OF NUCLEIC-ACIDS TO DIMYRISTOYLPHOSPHATIDYLCHOLINE-SPHINGOSINE LIPOSOMES [J].

KOIV, A ;

MUSTONEN, P ;

KINNUNEN, PKJ .

CHEMISTRY AND PHYSICS OF LIPIDS, 1994, 70 (01) :1-10

[23]

KRASNOW MA, 1982, J BIOL CHEM, V257, P2687

[24] DNA CONDENSATION BY THE RAT SPERMATIDAL PROTEIN TP2 SHOWS GC-RICH SEQUENCE PREFERENCE AND IS ZINC DEPENDENT [J].

KUNDU, TK ;

RAO, MRS .

BIOCHEMISTRY, 1995, 34 (15) :5143-5150

[25] MEASURED ENTROPY AND ENTHALPY OF HYDRATION AS A FUNCTION OF DISTANCE BETWEEN DNA DOUBLE HELICES [J].

LEIKIN, S ;

RAU, DC ;

PARSEGIAN, VA .

PHYSICAL REVIEW A, 1991, 44 (08) :5272-5278

[26] TRANSITION TO A COMPACT FORM OF DNA IN POLYMER SOLUTIONS [J].

LERMAN, LS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (08) :1886-+

[27] CATIONIC LIPOSOME-MEDIATED INTRAVENOUS GENE DELIVERY [J].

LIU, Y ;

LIGGITT, D ;

ZHONG, W ;

TU, GH ;

GAENSLER, K ;

DEBS, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (42) :24864-24870

[28] QUANTIFICATION OF THE EFFECT OF EXCLUDED-VOLUME ON DOUBLE-STRANDED DNA [J].

LOUIE, D ;

SERWER, P .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 242 (04) :547-558

[29] MONTE-CARLO SIMULATION STUDY OF ION DISTRIBUTION AND OSMOTIC-PRESSURE IN HEXAGONALLY ORIENTED DNA [J].

LYUBARTSEV, AP ;

NORDENSKIOLD, L .

JOURNAL OF PHYSICAL CHEMISTRY, 1995, 99 (25) :10373-10382

[30] CONDENSATION OF SUPERCOILED DNA INDUCED BY MNCL2 [J].

MA, CL ;

BLOOMFIELD, VA .

BIOPHYSICAL JOURNAL, 1994, 67 (04) :1678-1681

← 1 2 3 4 5 6 7 8 →