Lignans from the Fruits of Forsythia suspensa (Thunb.) Vahl Protect High-Density Lipoprotein during Oxidative Stress

被引：115

作者：

Chang, Min-Jung ^{[1
]}

Hung, Tran Manh ^{[2
]}

Min, Byung-Sun ^{[1
]}

Kim, Jin-Cheol ^{[3
]}

Woo, Mi Hee ^{[1
]}

Choi, Jae Sue ^{[4
]}

Lee, Hyeong Ky ^{[2
]}

Bae, KiHwan ^{[5
]}

机构：

[1] Catholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea

[3] Korea Res Inst Chem Technol, Taejon 305600, South Korea

[4] Pukyong Natl Univ, Fac Food Sci & Biotechnol, Pusan 608737, South Korea

[5] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2008年 / 72卷 / 10期

关键词：

Forsythia suspense; Oleaceae; lignan; human high-density lipoprotein; lipid peroxidation;

D O I：

10.1271/bbb.80392

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The objective of the present study was to investigate the beneficial properties lignan compounds obtained from the fruits of Forsythia suspensa (Thunb.) Vahl (Oleaccae) for protecting human high-density lipoprotein (HDL) against lipid peroxidation. The isolated compounds (1-8) inhibited the generation of thiobarbituric acid-reactive substances (TBARS) in a dose-dependent manner with IC50 values from 8.5 to 18.7 mu M, since HDL oxidation mediated by catalytic Cu2+. They also exerted an inhibitory effect against thermo-labile radical initiator (AAPH)-induced lipid peroxidation of HIM, with IC50 values from 12.1 to 51.1 mu M. Compounds 1 and 5 exerted inhibitory effects against the Cu2+-induced lipid peroxidation of HDL, as shown by an extended lag time prolongation at the concentration of 3.0 mu M. These results suggest that the antioxidative effects of F. suspensa are due to its lignans and that these constituents may be useful for preventing the oxidation of HDL.

引用

页码：2750 / 2755

页数：6

共 26 条

[1]

Chondroitin-4-sulfate protects high-density lipoprotein against copper-dependent oxidation [J].