One-Pot Synthesis of Hypervalent Iodine Reagents for Electrophilic Trifluoromethylation

被引：148

作者：

Matousek, Vaclav ^{[1
]}

Pietrasiak, Ewa ^{[1
]}

Schwenk, Rino ^{[1
]}

Togni, Antonio ^{[1
]}

机构：

[1] ETH, Dept Chem & Appl Biosci, Swiss Fed Inst Technol, CH-8093 Zurich, Switzerland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 13期

关键词：

COPPER-CATALYZED TRIFLUOROMETHYLATION; FLUORINE; REACTIVITY; ALKENES; ETHERS; ARYL;

D O I：

10.1021/jo400774u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Simplified syntheses suited for large scale preparations of the two hypervalent iodine reagents 1 and 2 for electrophilic trifluoromethylation are reported. In both cases, the stoichiometric oxidants sodium metaperiodate and tertbutyl hypochlorite have been replaced by trichloroisocyanuric acid. Reagent 1 is accessible in a one pot procedure from 2-iodobenzoic acid in 72% yield. Reagent 2 was prepared via fluoroiodane 11 in a considerably shorter reaction time and with no need of an accurate temperature control.

引用

页码：6763 / 6768

页数：6

共 42 条

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