Induction of mammalian cell death by a plant Bax inhibitor

被引：18

作者：

Yu, LH

Kawai-Yamada, M

Naito, M

Watanabe, K

Reed, JC

Uchimiya, H

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

[2] Burnham Inst, La Jolla, CA 92037 USA

来源：

FEBS LETTERS | 2002年 / 512卷 / 1-3期

关键词：

apoptosis; AtBI-1; Bax; chromatin condensation; caspase inhibitor;

D O I：

10.1016/S0014-5793(02)02230-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arabidopsis thaliana AtBI-1 is an orthologue of mammalian Bax inhibitor-1 capable of suppressing Bax-induced cell death in yeast as well as mammalian cells. Here Ne investigated whether or not AtBI-1 suppresses Bax-induced cell death using human fibrosarcoma HT1080 cells. Surprisingly, AtBI-1 did not block Bax-induced cell death. but it triggered apoptotic cell death in mammalian cells. The proapoptotic effect of AtBI-I as blocked by the X-linked caspase inhibitor XIAP, suggesting that the cell death caused by AtBI-1 is similar to that caused by Bax. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：308 / 312

页数：5

共 15 条

[1] Burns TF, 2001, J BIOL CHEM, V276, P37879
[2] X-linked IAP is a direct inhibitor of cell-death proteases
Deveraux, QL
Takahashi, R
Salvesen, GS
Reed, JC
[J]. NATURE, 1997, 388 (6639) : 300 - 304
[3] IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
Deveraux, QL
Roy, N
Stennicke, HR
Van Arsdale, T
Zhou, Q
Srinivasula, SM
Alnemri, ES
Salvesen, GS
Reed, JC
[J]. EMBO JOURNAL, 1998, 17 (08) : 2215 - 2223
[4] Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases
Fujita, N
Nagahashi, A
Nagashima, K
Rokudai, S
Tsuruo, T
[J]. ONCOGENE, 1998, 17 (10) : 1295 - 1304
[5] NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis
Hirotani, M
Zhang, YK
Fujita, N
Naito, M
Tsuruo, T
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (29) : 20415 - 20420
[6] Evolutionally conserved plant homologue of the Bax Inhibitor-1 (BI-1) gene capable of suppressing Bax-induced cell death in yeast
Kawai, M
Pan, L
Reed, JC
Uchimiya, H
[J]. FEBS LETTERS, 1999, 464 (03) : 143 - 147
[7] Mammalian Bax-induced plant cell death can be down-regulated by overexpression of Arabidopsis Bax Inhibitor-1 (AtBl-1)
Kawai-Yamada, M
Jin, LH
Yoshinaga, K
Hirata, A
Uchimiya, H
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (21) : 12295 - 12300
[8] Bax-induced cell death in tobacco is similar to the hypersensitive response
Lacomme, C
Cruz, SS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (14) : 7956 - 7961
[9] Programmed cell death, mitochondria and the plant hypersensitive response
Lam, E
Kato, N
Lawton, M
[J]. NATURE, 2001, 411 (6839) : 848 - 853
[10] Caspase remodeling of the spectrin membrane skeleton during lens development and aging
Lee, A
Morrow, JS
Fowler, VM
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (23) : 20735 - 20742

← 1 2 →