Environmental pH-sensitive polymeric micelles for cancer diagnosis and targeted therapy

被引：246

作者：

Gao, Guang Hui ^{[1
]}

Li, Yi ^{[1
]}

Lee, Doo Sung ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Dept Polymer Sci & Engn, Theranost Macromol Res Ctr, Suwon 440746, South Korea

来源：

JOURNAL OF CONTROLLED RELEASE | 2013年 / 169卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Polymeric micelles; Nanoparticles; pH sensitive; Cancer diagnosis; Targeted therapy; BLOCK-COPOLYMER MICELLES; TRIGGERED DRUG-RELEASE; INTRACELLULAR PH; GENE DELIVERY; VASCULAR-PERMEABILITY; EXTRACELLULAR PH; TUMOR; NANOPARTICLES; NANOCARRIERS; ASSEMBLIES;

D O I：

10.1016/j.jconrel.2012.11.012

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The delivery and control over the release of hydrophobic imaging markers for cancer diagnosis or pharmaceutical agents for targeted therapy are of considerable interest. Nano-sized pH-sensitive polymeric micelles that rely on the enhanced permeability and retention (EPR) of vasculature and the low-pH microenvironment in cancer tissue are emerging as stimuli-responsive targeted therapies that can simultaneously release diagnostic and therapeutic agents into a cancerous region. This review focuses on the developments of pH-sensitive polymeric micelles and their biomedical applications in cancer diagnosis and targeted therapy. (C) 2012 Elsevier B. V. All rights reserved.

引用

收藏

页码：180 / 184

页数：5

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