Will the real integrin please stand up?

被引:24
作者
Liddington, RC [1 ]
机构
[1] Burnham Inst, Program Cell Adhes, La Jolla, CA 92037 USA
关键词
D O I
10.1016/S0969-2126(02)00766-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent structure-function studies of integrins are beginning to unravel the mechanism of signal transduction across the plasma membrane, but controversy exists over the nature of the conformational changes underlying this process.
引用
收藏
页码:605 / 607
页数:3
相关论文
共 16 条
[1]   A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro [J].
Baker, EK ;
Tozer, EC ;
Pfaff, M ;
Shattil, SJ ;
Loftus, JC ;
Ginsberg, MH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) :1973-1978
[2]   Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation [J].
Beglova, N ;
Blacklow, SC ;
Takagi, J ;
Springer, TA .
NATURE STRUCTURAL BIOLOGY, 2002, 9 (04) :282-287
[3]   Structural aspects of heterotrimeric G-protein signaling [J].
Bohm, A ;
Gaudet, R ;
Sigler, PB .
CURRENT OPINION IN BIOTECHNOLOGY, 1997, 8 (04) :480-487
[4]   Structural basis of collagen recognition by integrin α2β1 [J].
Emsley, J ;
Knight, CG ;
Farndale, RW ;
Barnes, MJ ;
Liddington, RC .
CELL, 2000, 101 (01) :47-56
[5]   Integrins and anoikis [J].
Frisch, SM ;
Ruoslahti, E .
CURRENT OPINION IN CELL BIOLOGY, 1997, 9 (05) :701-706
[6]   Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on αIIbβ3 integrin conformation and oligomerization [J].
Hantgan, RR ;
Paumi, C ;
Rocco, M ;
Weisel, JW .
BIOCHEMISTRY, 1999, 38 (44) :14461-14474
[7]   Breaking the integrin hinge - A defined structural constraint regulates integrin signaling [J].
Hughes, PE ;
DiazGonzalez, F ;
Leong, L ;
Wu, CY ;
McDonald, JA ;
Shattil, SJ ;
Ginsberg, MH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (12) :6571-6574
[8]  
MOULD AP, 2002, J BIOL CHEM
[9]   Conformational changes in tertiary structure near the ligand binding site of an integrin I domain [J].
Oxvig, C ;
Lu, CF ;
Springer, TA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) :2215-2220
[10]   Networks and crosstalk: integrin signalling spreads [J].
Schwartz, MA ;
Ginsberg, MH .
NATURE CELL BIOLOGY, 2002, 4 (04) :E65-E68