Synthesis of antimicrobial natural products targeting FtsZ:: (±)-Dichamanetin and (±)-2′"-hydroxy-5"-benzylisouvarinol-B

被引：86

作者：

Urgaonkar, S

La Pierre, HS

Meir, I

Lund, H

RayChaudhuri, D

Shaw, JT

机构：

[1] Broad Inst Harvard & MIT, Chem Biol Program, Cambridge, MA 02141 USA

[2] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 25期

关键词：

D O I：

10.1021/ol052269z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.

引用

页码：5609 / 5612

页数：4

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