Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines

被引：73

作者：

Bai, NS

Lai, CS

He, K

Zhou, Z

Zhang, L

Quan, Z

Zhu, NQ

Zheng, QY

Pan, MH

Ho, CT

机构：

[1] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA

[2] Natl Kaohsiung Marine Univ, Dept Seafood Sci, Kaohsiung, Taiwan

[3] PureWorld Bot Inc, S Hackensack, NJ 07606 USA

[4] Fudan Univ, Coll Pharm, Shanghai 200032, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 04期

关键词：

D O I：

10.1021/np050437q

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS cancer cells. Compounds 3 and 4, two alpha-methylene gamma-lactone-bearing sesquiterpenes, were modestly active in these assays.

引用

页码：531 / 535

页数：5

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