Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents

被引：77

作者：

Ottesen, LK ^{[1
]}

Ek, F ^{[1
]}

Olsson, R ^{[1
]}

机构：

[1] ACADIA Pharmaceut AB, S-20512 Malmo, Sweden

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 09期

关键词：

D O I：

10.1021/ol0600234

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO2Me) gave excellent yields (89%).

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收藏

页码：1771 / 1773

页数：3

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