Metal-free one-pot synthesis of 1,3-diazaheterocyclic compounds via I2-mediated oxidative C-N bond formation

被引：65

作者：

Tian, Xianhai ^{[1
]}

Song, Lina ^{[1
]}

Li, Ertong ^{[1
]}

Wang, Qiang ^{[2
]}

Yu, Wenquan ^{[1
]}

Chang, Junbiao ^{[1
,3
]}

机构：

[1] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan Province, Peoples R China

[2] Henan Acad Sci, High & New Technol Res Ctr, Zhengzhou 450002, Henan Province, Peoples R China

[3] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450001, Henan Province, Peoples R China

来源：

RSC ADVANCES | 2015年 / 5卷 / 76期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

BENZIMIDAZOLE DERIVATIVES; MOLECULAR-IODINE; EFFICIENT SYNTHESIS; QUINAZOLINONES; SCAFFOLD; 2-IMIDAZOLINES; HETEROCYCLES; CYCLIZATION; CONVERSION; ALDEHYDES;

D O I：

10.1039/c5ra11262a

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A one-pot I-2-mediated annulation reaction of substrates containing diamino groups and aldehydes has been developed via oxidative C-N bond formation. This general and environmentally benign synthetic approach provides facile access to a variety of 1,3-diazaheterocyclic compounds, including quinazolinones, benzimidazoles, and cyclic amidines.

引用

页码：62194 / 62201

页数：8

共 64 条

[1]

Building Heterocyclic Systems with RC(OR)2+ Carbocations in Recyclable Bronsted Acidic Ionic Liquids: Facile Synthesis of 1-Substituted 1H-1,2,3,4-Tetrazoles, Benzazoles and Other Ring Systems with CH(OEt)3 and EtC(OEt)3 in [EtNH3][NO3] and [PMIM(SO3H)][OTf] [J].