Effects of chronic beta-amyloid treatment on fatty acid incorporation into rat brain

被引：7

作者：

Brining, SK

Jones, CR

Chang, MCJ

机构：

[1] National Institutes of Health, MSC 1582, Building 10, Bethesda, MD 20892-1582

来源：

NEUROBIOLOGY OF AGING | 1996年 / 17卷 / 02期

关键词：

Beta-amyloid; Alzheimer's disease; Fatty acids; phospholipid incorporation; osmotic pump; rat brain; arachidonate; docosahexaenoate; palmitate;

D O I：

10.1016/0197-4580(95)02071-3

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The present study evaluated the effects of chronic A beta administration on radio-labeled plasma fatty acid incorporation in rat brain. A beta was chronically infused intraventricularly via an osmotic minipump, for 1 week, at a concentration of 460 mu M. After the infusion, fatty acid incorporation was quantified using an in vivo method developed in this laboratory. Three radiolabeled fatty acids were separately infused IV in awake animals. Biochemical analyses of fatty acid incorporation and histology for A beta showed no differences between control (vehicle infusion only) and experimental groups. However, in vitro tests on the cytotoxicity of A beta showed that it caused significant cell death relative to controls (PC-12 cells). The lack of effect of infused A beta on radiolabeled fatty acid incorporation is discussed.

引用

页码：301 / 309

页数：9

共 51 条

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