Next-Generation Sequencing for Diagnosis and Tailored Therapy: A Case Report of Astrovirus-Associated Progressive Encephalitis

被引：109

作者：

Fremond, M. -L. ^{[1
,2
]}

Perot, P. ^{[3
]}

Muth, E.

Cros, G. ^{[1
,2
]}

Dumarest, M. ^{[3
]}

Mahlaoui, N. ^{[1
,2
,5
,6
]}

Seilhean, D. ^{[7
]}

Desguerre, I. ^{[8
]}

Hebert, C. ^{[4
]}

Corre-Catelin, N. ^{[9
]}

Neven, B. ^{[1
,2
]}

Lecuit, M. ^{[1
,10
,11
]}

Blanche, S. ^{[1
,2
]}

Picard, C. ^{[6
]}

Eloit, M. ^{[3
,4
]}

机构：

[1] Hop Univ Necker Enfants Malades, AP HP, Unite Immuno Hematol & Rhumatol Pediat, Paris, France

[2] Univ Paris 05, Sorbonne Paris Cite, Inst Imagine, Paris, France

[3] INSERM U1117, Inst Pasteur, Pathogen Discovery Lab, Biol Infect Unit, Paris, France

[4] PathoQuest, Paris, France

[5] INSERM U1163, Lab Genet Humaine Malad Infectieuses, Paris, France

[6] Hop Univ Necker Enfants Malades, AP HP, Ctr Reference Deficits Immunitaires Hereditaires, Paris, France

[7] Univ Paris 06, Hop Univ Pitie Salpetrire, Sorbonne Univ, Dept Neuropathol, Paris, France

[8] Hop Univ Necker Enfants Malades, Univ Paris Descartes, Unite Neuropediat, Paris, France

[9] Invest Clin & Acces Ressources Biolog, Inst Pasteur, Paris, France

[10] Paris Descartes Univ, Sorbonne Paris Cite, Necker Enfants Malades Univ Hosp, Inst Imagine,Div Infect Dis & Trop Med, Paris, France

[11] INSERM U1117, Institut Pasteur, Biol Infect Unit, Paris, France

来源：

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | 2015年 / 4卷 / 03期

关键词：

agammaglobulinemia; astrovirus; Bruton; encephalitis;

D O I：

10.1093/jpids/piv040

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

A boy with X-linked agammaglobulinemia experienced progressive global motor decline, cerebellar syndrome, and epilepsy. All standard polymerase chain reactions for neurotropic viruses were negative on cerebrospinal fluid and brain biopsy. Next-generation sequencing allowed fast identification of a new astrovirus strain (HAstV-VA1/HMO-C-PA), which led to tailor the patient's treatment, with encouraging clinical monitoring over 1 year.

引用

页码：E53 / E57

页数：5

共 19 条

[1]

Detection of a Novel Astrovirus in Brain Tissue of Mink Suffering from Shaking Mink Syndrome by Use of Viral Metagenomics [J].

Blomstrom, Anne-Lie ;

Widen, Frederik ;

Hammer, Anne-Sofie ;

Belak, Sandor ;

Berg, Mikael .

JOURNAL OF CLINICAL MICROBIOLOGY, 2010, 48 (12) :4392-4396

[2]

Neurotropic Astrovirus in Cattle with Nonsuppurative Encephalitis in Europe [J].

Bouzalas, Ilias G. ;

Wuethrich, Daniel ;

Walland, Julia ;

Droegemueller, Cord ;

Zurbriggen, Andreas ;

Vandevelde, Marc ;

Oevermann, Anna ;

Bruggmann, Remy ;

Seuberlich, Torsten .

JOURNAL OF CLINICAL MICROBIOLOGY, 2014, 52 (09) :3318-3324

[3]

Astrovirus VA1/HMO-C: An Increasingly Recognized Neurotropic Pathogen in Immunocompromised Patients [J].

Brown, Julianne R. ;

Morfopoulou, Sofia ;

Hubb, Jonathan ;

Emmett, Warren A. ;

Ip, Winnie ;

Shah, Divya ;

Brooks, Tony ;

Paine, Simon M. L. ;

Anderson, Glenn ;

Virasami, Alex ;

Tong, C. Y. William ;

Clark, Duncan A. ;

Plagnol, Vincent ;

Jacques, Thomas S. ;

Qasim, Waseem ;

Hubank, Mike ;

Breuer, Judith .

CLINICAL INFECTIOUS DISEASES, 2015, 60 (06) :881-888

[4]

Serological Studies Confirm the Novel Astrovirus HMOAstV-C as a Highly Prevalent Human Infectious Agent [J].

Burbelo, Peter D. ;

Ching, Kathryn H. ;

Esper, Frank ;

Iadarola, Michael J. ;

Delwart, Eric ;

Lipkin, W. Ian ;

Kapoor, Amit .

PLOS ONE, 2011, 6 (08)

[5]

Analysis of clinical presentations of Bruton Disease: A review of 20 years of accumulated data from pediatric patients at Severance Hospital [J].

Chun, Jin-Kyong ;

Lee, Taek Jin ;

Song, Jae Woo ;

Linton, John A. ;

Kim, Dong Soo .

YONSEI MEDICAL JOURNAL, 2008, 49 (01) :28-36

[6]

Primary B Cell Immunodeficiencies: Comparisons and Contrasts [J].

Conley, Mary Ellen ;

Dobbs, A. Kerry ;

Farmer, Dana M. ;

Kilic, Sebnem ;

Paris, Kenneth ;

Grigoriadou, Sofia ;

Coustan-Smith, Elaine ;

Howard, Vanessa ;

Campana, Dario .

ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :199-227

[7]

Astrovirus infections in humans and animals - Molecular biology, genetic diversity, and interspecies transmissions [J].

De Benedictis, Paola ;

Schultz-Cherry, Stacey ;

Burnham, Andrew ;

Cattoli, Giovanni .

INFECTION GENETICS AND EVOLUTION, 2011, 11 (07) :1529-1544

[8]

Identification of a Novel Astrovirus (Astrovirus VA1) Associated with an Outbreak of Acute Gastroenteritis [J].

Finkbeiner, Stacy R. ;

Li, Yan ;

Ruone, Susan ;

Conrardy, Christina ;

Gregoricus, Nicole ;

Toney, Denise ;

Virgin, Herbert W. ;

Anderson, Larry J. ;

Vinje, Jan ;

Wang, David ;

Tong, Suxiang .

JOURNAL OF VIROLOGY, 2009, 83 (20) :10836-10839

[9]

Beyond viruses: Clinical profiles and etiologies associated with encephalitis [J].

Glaser, C. A. ;

Honarmand, S. ;

Anderson, L. J. ;

Schnurr, D. P. ;

Forghani, B. ;

Cossen, C. K. ;

Schuster, F. L. ;

Christie, L. J. ;

Tureen, J. H. .

CLINICAL INFECTIOUS DISEASES, 2006, 43 (12) :1565-1577

[10]

Enteroviral infections in primary immunodeficiency (PID): A survey of morbidity and mortality [J].

Halliday, E ;

Winkelstein, J ;

Webster, ADB .

JOURNAL OF INFECTION, 2003, 46 (01) :1-8

← 1 2 →