Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection

被引：384

作者：

Bertoletti, Antonio ^{[2
,3
,4
]}

Ferrari, Carlo ^{[1
]}

机构：

[1] Azienda Osped Univ Parma, Unit Infect Dis & Hepatol, Lab Viral Immunopathol, I-43100 Parma, Italy

[2] ASTAR, Infect & Immun Program, Singapore Inst Clin Sci, Singapore, Singapore

[3] Duke NUS Grad Med Sch, Program Emerging Viral Dis, Singapore, Singapore

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 117595, Singapore

来源：

GUT | 2012年 / 61卷 / 12期

关键词：

REGULATORY T-CELLS; TLR7 AGONIST GS-9620; HUMAN HEPATOCYTES; INTERFERON-ALPHA; LONGITUDINAL ANALYSIS; LAMIVUDINE TREATMENT; GENOMIC ANALYSIS; SURFACE-ANTIGEN; HOST RESPONSE; LIVER-DAMAGE;

D O I：

10.1136/gutjnl-2011-301073

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Knowledge of the immunological events necessary to control hepatitis B virus (HBV) infection has accelerated in recent years, but their translation towards therapeutic strategies able to achieve a durable HBV suppression has been challenging. The scenario of how HBV deals with the host immunity is presented and used to discuss how the immune response can be harnessed to potentially achieve infection control.

引用

收藏

页码：1754 / 1764

页数：11

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