Synthesis and characterization of Fe- and Co-based ferrite nanoparticles and study of the T1 and T2 relaxivity of chitosan-coated particles

被引:18
作者
Hoque, S. Manjura [1 ,2 ]
Srivastava, C. [2 ]
Srivastava, N. [2 ]
Venkateshan, N. [2 ]
Chattopadhyay, K. [2 ]
机构
[1] Bangladesh Atom Energy Commiss, Atom Energy Ctr, Div Mat Sci, Dhaka, Bangladesh
[2] Indian Inst Sci, Dept Mat Engn, Bangalore 560012, Karnataka, India
关键词
MAGNETIC NANOPARTICLES; CONTRAST AGENT; HYPERTHERMIA; OPTIMIZATION; CELLS;
D O I
10.1007/s10853-012-6800-9
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
In pursuit of newer and more effective contrast agents for magnetic resonance imaging, we report in this article the use of biocompatible chitosan-coated ferrite nanoparticles of different kinds with a view to determine their potential applications as the contrast agents in the field of nuclear magnetic resonance. The single-phase ferrite particles were synthesized by chemical co-precipitation (CoFe2O4 and Fe3O4) and by applying ultrasonic vibration (CoFe2O4 and Co0.8Zn0.2Fe2O4). Although magnetic anisotropy of CoFe2O4 nanoparticle leads to finite coercivity even for nanoensembles, it has been reduced significantly to a minimum level by applying ultrasonic vibration. Fe3O4 synthesized by chemical co-precipitation yielded particles which already possess negligible coercivity and remanence. Substitution of Co by Zn in CoFe2O4 increases the magnetization significantly with a small increase in coercivity and remanence. Particles synthesized by the application of ultrasonic vibration leads to the higher values of T-2 relaxivities than by chemical coprecipitation. We report that the T-2 relaxivities of these particles are of two orders of magnitude higher than corresponding T-1 relaxivities. Thus, these particles are evidently suitable as contrast agent for T-2 weighted MR images.
引用
收藏
页码:812 / 818
页数:7
相关论文
共 27 条
[1]   Synthesis of amine-stabilized aqueous colloidal iron oxide nanoparticles [J].
Aslam, M. ;
Schultz, Elise A. ;
Sun, Tao ;
Meade, Thomas ;
Dravid, Vinayak P. .
CRYSTAL GROWTH & DESIGN, 2007, 7 (03) :471-475
[2]   Magnetic nanoparticles for drug delivery [J].
Dobson, J .
DRUG DEVELOPMENT RESEARCH, 2006, 67 (01) :55-60
[3]   Intracellular heating of living cells through Neel relaxation of magnetic nanoparticles [J].
Fortin, Jean-Paul ;
Gazeau, Florence ;
Wilhelm, Claire .
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2008, 37 (02) :223-228
[4]   Nanoscale magnetic biotransport with application to magnetofection [J].
Furlani, E. P. ;
Ng, K. C. .
PHYSICAL REVIEW E, 2008, 77 (06)
[5]   Optimizing magnetic nanoparticle design for nanothermotherapy [J].
Gazeau, Florence ;
Levy, Michael ;
Wilhelm, Claire .
NANOMEDICINE, 2008, 3 (06) :831-844
[6]   Chitosan-coated Ferrite (Fe3O4) Nanoparticles as a T2 Contrast Agent for Magnetic Resonance Imaging [J].
Hong, Sungwook ;
Chang, Yongmin ;
Rhee, Ilsu .
JOURNAL OF THE KOREAN PHYSICAL SOCIETY, 2010, 56 (03) :868-873
[7]   Effects of magnetic fluid hyperthermia (MFH) on C3H mammary carcinoma in vivo [J].
Jordan, A ;
Scholz, R ;
Wust, P ;
Fahling, H ;
Krause, J ;
Wlodarczyk, W ;
Sander, B ;
Vogl, T ;
Felix, R .
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 1997, 13 (06) :587-605
[8]   Effects of Shape and Size of Cobalt Ferrite Nanostructures on Their MRI Contrast and Thermal Activation [J].
Joshi, Hrushikesh M. ;
Lin, Yen Po ;
Aslam, Mohammed ;
Prasad, P. V. ;
Schultz-Sikma, Elise A. ;
Edelman, Robert ;
Meade, Thomas ;
Dravid, Vinayak P. .
JOURNAL OF PHYSICAL CHEMISTRY C, 2009, 113 (41) :17761-17767
[9]   Improvement in ductility of chitosan through blending and copolymerization with PEG: FTIR investigation of molecular interactions [J].
Kolhe, P ;
Kannan, RM .
BIOMACROMOLECULES, 2003, 4 (01) :173-180
[10]  
Lee JH, 2007, NAT MED, V13, P95, DOI [10.1038/nm1467, 10.20659/jfp.13.1_95]