The genetics of early telencephalon patterning:: some assembly required

被引：267

作者：

Hebert, Jean M. ^{[1
,2
]}

Fishell, Gord ^{[3
,4
]}

机构：

[1] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Mol Genet, Bronx, NY 10461 USA

[3] NYU, Smilow Neurosci Program, New York, NY 10016 USA

[4] NYU, Dept Cell Biol, New York, NY 10016 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2008年 / 9卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrn2463

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The immense range of human behaviours is rooted in the complex neural networks of the cerebrum. The creation of these networks depends on the precise integration of specific neuronal subtypes that are born in different regions of the telencephalon. Here, using the mouse as a model system, we review how these proliferative zones are established. Moreover, we discuss how these regions can be traced back in development to the function of a few key genes, including those that encode fibroblast growth factors (FGFs), sonic hedgehog (SHH), bone morphogenetic proteins (BMPs), forkhead box G1 (FoxG1), paired box 6 (PAx6) and LIM homeobox protein 2 (LHx2), that pattern the early telencephalon.

引用

页码：678 / 685

页数：8

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