Proteomics and the kidney

被引：91

作者：

Knepper, MA ^{[1
]}

机构：

[1] NHLBI, Kidney & Electrolyte Metab Lab, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2002年 / 13卷 / 05期

关键词：

D O I：

10.1097/01.ASN.0000014782.37591.C7

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Proteomics can be defined as "the systematic analysis of proteins for their identity, quantity, and function." The central concept is "multiplexing," i.e., simultaneous analysis of all proteins in a defined protein population. rather than investigation of one protein at a time, as in traditional biochemistry. Two major approaches have been described: (1) mass spectrometry-based approaches and (2) protein micro-array approaches. The purpose of this Science Watch article is to describe the fundamental features of these two approaches and to speculate on how proteomics will be useful in nephrology and nephrology research in the coming years.

引用

页码：1398 / 1408

页数：11

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