Macrophage polarization and plasticity in health and disease

被引：409

作者：

Biswas, Subhra K. ^{[1
]}

Chittezhath, Manesh ^{[1
]}

Shalova, Irina N. ^{[1
]}

Lim, Jyue-Yuan ^{[1
]}

机构：

[1] ASTAR, Singapore Immunol Network SIgN, Singapore 138648, Singapore

来源：

IMMUNOLOGIC RESEARCH | 2012年 / 53卷 / 1-3期

关键词：

Macrophage; Polarization; Disease; NF-KAPPA-B; TUMOR-ASSOCIATED MACROPHAGES; HYPOXIA-INDUCIBLE FACTORS; GENE-EXPRESSION; ENDOTOXIN TOLERANCE; HUMAN MONOCYTES; IMMUNE-RESPONSE; TRANSCRIPTIONAL REGULATION; ALTERNATIVE ACTIVATION; LINKS INFLAMMATION;

D O I：

10.1007/s12026-012-8291-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The role of myelomonocytic cells like monocytes and macrophages as first line of host defense is well established. Recent understanding of these cells using systems biology, transgenesis and in disease models has brought them to a center stage in orchestrating crucial functions during homeostasis and pathogenesis. Thus, understanding the functional diversity of these cells in health and disease as well as the mechanisms that control these events would be crucial for designing strategies for regulating disease and reinstate homeostasis.

引用

页码：11 / 24

页数：14

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