Interneuron cell types are fit to function

被引：746

作者：

Kepecs, Adam ^{[1
]}

Fishell, Gordon ^{[2
]}

机构：

[1] Cold Spring Harbor Lab, New York, NY 11724 USA

[2] NYU, Langone Med Ctr, New York, NY 10016 USA

来源：

NATURE | 2014年 / 505卷 / 7483期

基金：

美国国家卫生研究院;

关键词：

EXPRESSING GABAERGIC NEURONS; CAUDAL GANGLIONIC EMINENCE; FATE MAPPING REVEALS; FAST-SPIKING CELLS; CORTICAL INTERNEURONS; IMMUNOREACTIVE INTERNEURONS; INHIBITORY INTERNEURONS; SHUNTING INHIBITION; PYRAMIDAL CELLS; GENE-FUNCTION;

D O I：

10.1038/nature12983

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Understanding brain circuits begins with an appreciation of their component parts - the cells. Although GABAergic interneurons are a minority population within the brain, they are crucial for the control of inhibition. Determining the diversity of these interneurons has been a central goal of neurobiologists, but this amazing cell type has so far defied a generalized classification system. Interneuron complexity within the telencephalon could be simplified by viewing them as elaborations of a much more finite group of developmentally specified cardinal classes that become further specialized as they mature. Our perspective emphasizes that the ultimate goal is to dispense with classification criteria and directly define interneuron types by function.

引用

收藏

页码：318 / 326

页数：9

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