Recent progress in tartaric acid-modified Raney nickel system for enantio-differentiating hydrogenation

被引：49

作者：

Sugimura, T ^{[1
]}

机构：

[1] Himeji Inst Technol, Fac Sci, Kamigori, Hyogo 6781297, Japan

来源：

CATALYSIS SURVEYS FROM JAPAN | 1999年 / 3卷 / 01期

关键词：

tartaric acid-modified nickel; enantio-differentiating hydrogenation; prochiral ketone; optically active alcohol; stereochemical study;

D O I：

10.1023/A:1019007331446

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Tartaric acid-modified Raney nickel (TA-MRNi) is an enantio-differentiating catalyst for hydrogenation of ketones. The stereochemical models explaining the enantio-differentiation of beta-ketoester and 2-alkanone were unified as an extended stereochemical model by the experimental supports. Based on this new model, a working hypothesis to improve the enantiomeric excess (ee) of the beta-ketoester/TA-MRNi system was developed, and the ee was improved to 96%. By further fine tuning of this system, almost perfect enantio-differentiation resulting in over 98% ee was achieved.

引用

页码：37 / 42

页数：6

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