Aging of mesenchymal stem cells

被引:492
作者
Sethe, S
Scutt, A
Stolzing, A [1 ]
机构
[1] Univ Sheffield, Kroto Res Inst, Sheffield S10 2TN, S Yorkshire, England
[2] Univ Sheffield, Ctr Nanosci & Technol, Sheffield S10 2TN, S Yorkshire, England
[3] Univ Sheffield, Sheffield Inst Biotechnol Law & Eth, Sheffield S10 2TN, S Yorkshire, England
关键词
aging; mesenchymal stem cell; senescence; telomeres;
D O I
10.1016/j.arr.2005.10.001
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The role of adult mesenchymal stem cells (MSC) in tissue maintenance and regeneration has received significant attention of late. Questions arise to what extent these cells are either subject to, or causes of aging; whether age-related changes in these cells are due to intrinsic factors or induced by the somatic environment. This review collates and examines recent data in support of these different theories. By means of introduction, a brief overview is given of current MSC definitions and their basic role in tissue regeneration followed by a comparative analysis of gerontological studies involving MSC. Evidence for extrinsic aging and various aging markers relating to morphology, proliferation, signalling, senescence markers, telomeres and telomerase, and other indicators is discussed. We observe that while the literature might often appear to conflict, many apparent discrepancies are attributable to inconsistent methods of extracting and isolating MSC which in fact contains various subsets of adult stem cells, varying not only in their differentiation potential but also in their vulnerability to senescence-ranging from quasi-somatic lifespan to perennial vigour. Thus, mesenchymal stem cells emerge as both subject to and key mediators of organismal aging. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:91 / 116
页数:26
相关论文
共 198 条
[1]   Quiescent neural cells regain multipotent stem cell characteristics influenced by adult neural stem cells in co-culture [J].
Alexanian, AR ;
Kurpad, SN .
EXPERIMENTAL NEUROLOGY, 2005, 191 (01) :193-197
[2]   TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation [J].
Alliston, T ;
Choy, L ;
Ducy, P ;
Karsenty, G ;
Derynck, R .
EMBO JOURNAL, 2001, 20 (09) :2254-2272
[3]   Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role? [J].
Allsopp, RC ;
Weissman, IL .
ONCOGENE, 2002, 21 (21) :3270-3273
[4]   Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase [J].
Armour, KE ;
Armour, KJ ;
Gallagher, ME ;
Gödecke, A ;
Helfrich, MH ;
Reid, DM ;
Ralston, SH .
ENDOCRINOLOGY, 2001, 142 (02) :760-766
[5]   mTert expression correlates with telomerase activity during the differentiation of murine embryonic stem cells [J].
Armstrong, L ;
Lako, M ;
Lincoln, J ;
Cairns, PM ;
Hole, N .
MECHANISMS OF DEVELOPMENT, 2000, 97 (1-2) :109-116
[6]   Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy [J].
Baksh, D ;
Song, L ;
Tuan, RS .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2004, 8 (03) :301-316
[7]   Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy [J].
Banfi, A ;
Muraglia, A ;
Dozin, B ;
Mastrogiacomo, M ;
Cancedda, R ;
Quarto, R .
EXPERIMENTAL HEMATOLOGY, 2000, 28 (06) :707-715
[8]   Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion [J].
Baxter, MA ;
Wynn, RF ;
Jowitt, SN ;
Wraith, JE ;
Fairbairn, LJ ;
Bellantuono, I .
STEM CELLS, 2004, 22 (05) :675-682
[9]  
Bergman RJ, 1996, J BONE MINER RES, V11, P568
[10]   Extracellular matrix proteoglycans control the fate of bone marrow stromal cells [J].
Bi, YM ;
Stuelten, CH ;
Kilts, T ;
Wadhwa, S ;
Iozzo, RV ;
Robey, PG ;
Chen, XD ;
Young, MF .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (34) :30481-30489