The role of adult mesenchymal stem cells (MSC) in tissue maintenance and regeneration has received significant attention of late. Questions arise to what extent these cells are either subject to, or causes of aging; whether age-related changes in these cells are due to intrinsic factors or induced by the somatic environment. This review collates and examines recent data in support of these different theories. By means of introduction, a brief overview is given of current MSC definitions and their basic role in tissue regeneration followed by a comparative analysis of gerontological studies involving MSC. Evidence for extrinsic aging and various aging markers relating to morphology, proliferation, signalling, senescence markers, telomeres and telomerase, and other indicators is discussed. We observe that while the literature might often appear to conflict, many apparent discrepancies are attributable to inconsistent methods of extracting and isolating MSC which in fact contains various subsets of adult stem cells, varying not only in their differentiation potential but also in their vulnerability to senescence-ranging from quasi-somatic lifespan to perennial vigour. Thus, mesenchymal stem cells emerge as both subject to and key mediators of organismal aging. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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Med Coll Wisconsin, Neurosci Res Lab, Dept Neurosurg, VAMC, Milwaukee, WI 53295 USAMed Coll Wisconsin, Neurosci Res Lab, Dept Neurosurg, VAMC, Milwaukee, WI 53295 USA
Alexanian, AR
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Kurpad, SN
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Med Coll Wisconsin, Neurosci Res Lab, Dept Neurosurg, VAMC, Milwaukee, WI 53295 USAMed Coll Wisconsin, Neurosci Res Lab, Dept Neurosurg, VAMC, Milwaukee, WI 53295 USA
机构:Univ Calif San Francisco, Dept Growth & Dev, Cell Biol Program, San Francisco, CA 94143 USA
Alliston, T
;
Choy, L
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机构:Univ Calif San Francisco, Dept Growth & Dev, Cell Biol Program, San Francisco, CA 94143 USA
Choy, L
;
Ducy, P
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机构:Univ Calif San Francisco, Dept Growth & Dev, Cell Biol Program, San Francisco, CA 94143 USA
Ducy, P
;
Karsenty, G
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机构:Univ Calif San Francisco, Dept Growth & Dev, Cell Biol Program, San Francisco, CA 94143 USA
Karsenty, G
;
Derynck, R
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Univ Calif San Francisco, Dept Growth & Dev, Cell Biol Program, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Growth & Dev, Cell Biol Program, San Francisco, CA 94143 USA
机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Baxter, MA
;
Wynn, RF
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机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Wynn, RF
;
Jowitt, SN
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机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Jowitt, SN
;
Wraith, JE
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机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Wraith, JE
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Fairbairn, LJ
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机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Fairbairn, LJ
;
Bellantuono, I
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Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, EnglandRoyal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
机构:
Med Coll Wisconsin, Neurosci Res Lab, Dept Neurosurg, VAMC, Milwaukee, WI 53295 USAMed Coll Wisconsin, Neurosci Res Lab, Dept Neurosurg, VAMC, Milwaukee, WI 53295 USA
Alexanian, AR
;
Kurpad, SN
论文数: 0引用数: 0
h-index: 0
机构:
Med Coll Wisconsin, Neurosci Res Lab, Dept Neurosurg, VAMC, Milwaukee, WI 53295 USAMed Coll Wisconsin, Neurosci Res Lab, Dept Neurosurg, VAMC, Milwaukee, WI 53295 USA
机构:Univ Calif San Francisco, Dept Growth & Dev, Cell Biol Program, San Francisco, CA 94143 USA
Alliston, T
;
Choy, L
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Francisco, Dept Growth & Dev, Cell Biol Program, San Francisco, CA 94143 USA
Choy, L
;
Ducy, P
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Francisco, Dept Growth & Dev, Cell Biol Program, San Francisco, CA 94143 USA
Ducy, P
;
Karsenty, G
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Francisco, Dept Growth & Dev, Cell Biol Program, San Francisco, CA 94143 USA
Karsenty, G
;
Derynck, R
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Growth & Dev, Cell Biol Program, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Growth & Dev, Cell Biol Program, San Francisco, CA 94143 USA
机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Baxter, MA
;
Wynn, RF
论文数: 0引用数: 0
h-index: 0
机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Wynn, RF
;
Jowitt, SN
论文数: 0引用数: 0
h-index: 0
机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Jowitt, SN
;
Wraith, JE
论文数: 0引用数: 0
h-index: 0
机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Wraith, JE
;
Fairbairn, LJ
论文数: 0引用数: 0
h-index: 0
机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Fairbairn, LJ
;
Bellantuono, I
论文数: 0引用数: 0
h-index: 0
机构:
Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, EnglandRoyal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England