Neurohormonal signaling pathways and the regulation of Alzheimer β-amyloid precursor metabolism

被引：34

作者：

Gandy, S ^{[1
]}

机构：

[1] NYU, Nathan S Kline Inst Psychiat Res, Dept Psychiat, Orangeburg, NY 10962 USA

[2] Rockefeller Univ, Fisher Ctr Alzheimer Res, New York, NY 10021 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1999年 / 10卷 / 07期

关键词：

D O I：

10.1016/S1043-2760(99)00166-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Postmenopausal women on estrogen replacement appear to have their relative risk of developing Alzheimer's disease diminished by about one half: Because brain amyloid accumulation plays a key role in initiating Alzheimer's pathology, it is attractive to postulate that estrogen might modulate Alzheimer's risk by inhibiting amyloid accumulation. Data and cell biological models supporting such a scenario are reviewed here.

引用

页码：273 / 279

页数：7

共 50 条

[1] Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition
Bales, KR
Verina, T
Dodel, RC
Du, YS
Altstiel, L
Bender, M
Hyslop, P
Johnstone, EM
Little, SP
Cummins, DJ
Piccardo, P
Ghetti, B
Paul, SM
[J]. NATURE GENETICS, 1997, 17 (03) : 263 - 264
[2] A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
Black, RA
Rauch, CT
Kozlosky, CJ
Peschon, JJ
Slack, JL
Wolfson, MF
Castner, BJ
Stocking, KL
Reddy, P
Srinivasan, S
Nelson, N
Boiani, N
Schooley, KA
Gerhart, M
Davis, R
Fitzner, JN
Johnson, RS
Paxton, RJ
March, CJ
Cerretti, DP
[J]. NATURE, 1997, 385 (6618) : 729 - 733
[3] Familial Alzheimer's disease-linked presenilin 1 variants elevate A beta 1-42/1-40 ratio in vitro and in vivo
Borchelt, DR
Thinakaran, G
Eckman, CB
Lee, MK
Davenport, F
Ratovitsky, T
Prada, CM
Kim, G
Seekins, S
Yager, D
Slunt, HH
Wang, R
Seeger, M
Levey, AI
Gandy, SE
Copeland, NG
Jenkins, NA
Price, DL
Younkin, SG
[J]. NEURON, 1996, 17 (05) : 1005 - 1013
[4] ACTIVATED RELEASE OF MEMBRANE-ANCHORED TGF-ALPHA IN THE ABSENCE OF CYTOSOL
BOSENBERG, MW
PANDIELLA, A
MASSAGUE, J
[J]. JOURNAL OF CELL BIOLOGY, 1993, 122 (01) : 95 - 101
[5] Evidence that tumor necrosis factor α converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor
Buxbaum, JD
Liu, KN
Luo, YX
Slack, JL
Stocking, KL
Peschon, JJ
Johnson, RS
Castner, BJ
Cerretti, DP
Black, RA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (43) : 27765 - 27767
[6] PROCESSING OF ALZHEIMER BETA-A4 AMYLOID PRECURSOR PROTEIN - MODULATION BY AGENTS THAT REGULATE PROTEIN-PHOSPHORYLATION
BUXBAUM, JD
GANDY, SE
CICCHETTI, P
EHRLICH, ME
CZERNIK, AJ
FRACASSO, RP
RAMABHADRAN, TV
UNTERBECK, AJ
GREENGARD, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) : 6003 - 6006
[7] PROTEIN-PHOSPHORYLATION INHIBITS PRODUCTION OF ALZHEIMER AMYLOID-BETA/A4 PEPTIDE
BUXBAUM, JD
KOO, EH
GREENGARD, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (19) : 9195 - 9198
[8] CHOLINERGIC AGONISTS AND INTERLEUKIN-1 REGULATE PROCESSING AND SECRETION OF THE ALZHEIMER BETA/A4 AMYLOID PROTEIN-PRECURSOR
BUXBAUM, JD
OISHI, M
CHEN, HI
PINKASKRAMARSKI, R
JAFFE, EA
GANDY, SE
GREENGARD, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) : 10075 - 10078
[9] Neuron loss in APP transgenic mice
Calhoun, ME
Wiederhold, KH
Abramowski, D
Phinney, AL
Probst, A
Sturchler-Pierrat, C
Staufenbiel, M
Sommer, B
Jucker, M
[J]. NATURE, 1998, 395 (6704) : 755 - 756
[10] CAPORASO GL, 1994, J NEUROSCI, V14, P3122

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