Neurohormonal signaling pathways and the regulation of Alzheimer β-amyloid precursor metabolism

被引：34

作者：

Gandy, S ^{[1
]}

机构：

[1] NYU, Nathan S Kline Inst Psychiat Res, Dept Psychiat, Orangeburg, NY 10962 USA

[2] Rockefeller Univ, Fisher Ctr Alzheimer Res, New York, NY 10021 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1999年 / 10卷 / 07期

关键词：

D O I：

10.1016/S1043-2760(99)00166-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Postmenopausal women on estrogen replacement appear to have their relative risk of developing Alzheimer's disease diminished by about one half: Because brain amyloid accumulation plays a key role in initiating Alzheimer's pathology, it is attractive to postulate that estrogen might modulate Alzheimer's risk by inhibiting amyloid accumulation. Data and cell biological models supporting such a scenario are reviewed here.

引用

页码：273 / 279

页数：7

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