Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

被引：13

作者：

Battilocchio, Claudio ^{[2
,3
]}

Baumann, Marcus ^{[2
]}

Baxendale, Ian R. ^{[2
]}

Biava, Mariangela ^{[3
]}

Kitching, Matthew O. ^{[2
]}

Ley, Steven V. ^{[2
]}

Martin, Rainer E. ^{[1
]}

Ohnmacht, Stephan A. ^{[1
]}

Tappin, Nicholas D. C. ^{[2
]}

机构：

[1] F Hoffmann La Roche Ltd, Div Pharmaceut, Chem Technol & Innovat, CH-4070 Basel, Switzerland

[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[3] Univ Roma La Sapienza, Dept Pharmaceut Chem & Technol, Rome, Italy

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

ligands; macrocycles; flow chemistry; solid-supported reagent; asymmetric synthesis; scale up; POLYUREA-ENCAPSULATED PALLADIUM; POLYMER-SUPPORTED REAGENTS; ORGANIC-SYNTHESIS; CATALYSTS; EFFICIENT; PYRIDINE-BIS(OXAZOLINE); SCAVENGERS; CHEMISTRY; IMMOBILIZATION; PARALLEL;

D O I：

10.1055/s-0031-1289676

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of PyBox ligands were prepared from commercially available chelidonic acid by a multistep flow sequence using mesoreactor technology. A chloro group introduced onto the ligand scaffold was subsequently exploited to give amine derivatives ready for immobilization through microencapsulation technologies.

引用

页码：635 / 647

页数：13

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