Multistep reactions using microreactor chemistry

被引：22

作者：

Ahmed-Omer, Batoul ^{[1
,2
]}

Barrow, David A. ^{[1
]}

Wirth, Thomas ^{[2
]}

机构：

[1] Cardiff Univ, Cardiff Sch Engn, Lab Appl Microsyst, Cardiff CF24 3AA, S Glam, Wales

[2] Cardiff Univ, Sch Chem, Cardiff CF10 3AT, S Glam, Wales

来源：

ARKIVOC | 2011年

基金：

英国工程与自然科学研究理事会;

关键词：

Catalysis; Heck reaction; metathesis; microreactors; multistep synthesis; RING-CLOSING METATHESIS; VISCOSITY IONIC LIQUID; HECK REACTION; FLOW; CATALYSIS; SYSTEM; MICRO;

D O I：

10.3998/ark.5550190.0012.404

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A microflow system for the investigation of multistep syntheses involving Pd-catalysed Heck reactions and Ru-catalysed ring-closing metathesis is described. A successful provision of reagent and catalyst delivery in a consecutive fashion allowed control over reaction parameters leading to fast optimisation. The performance of Heck reactions in multistep procedures was not as successful as in the single step coupling, whereas the ring-closing metathesis proved to be successful in the production of the desired compounds for further functionalisation.

引用

页码：26 / 36

页数：11

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