Compression and free expansion of single DNA molecules in nanochannels

被引：107

作者：

Reccius, CH ^{[1
]}

Mannion, JT ^{[1
]}

Cross, JD ^{[1
]}

Craighead, HG ^{[1
]}

机构：

[1] Cornell Univ, Sch Appl & Engn Phys, Ithaca, NY 14853 USA

来源：

PHYSICAL REVIEW LETTERS | 2005年 / 95卷 / 26期

关键词：

D O I：

10.1103/PhysRevLett.95.268101

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We investigated compression and ensuing expansion of long DNA molecules confined in nanochannels. Transverse confinement of DNA molecules in the nanofluidic channels leads to elongation of their unconstrained equilibrium configuration. The extended molecules were compressed by electrophoretically driving them into porelike constrictions inside the nanochannels. When the electric field was turned off, the DNA strands expanded. This expansion, the dynamics of which has not previously been observable in artificial systems, is explained by a model that is a variation of de Gennes's polymer model.

引用

页数：4

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