Yeast viral killer toxins: lethality and self-protection

被引：223

作者：

Schmitt, MJ ^{[1
]}

Breinig, F ^{[1
]}

机构：

[1] Univ Saarland, D-66041 Saarbrucken, Germany

来源：

NATURE REVIEWS MICROBIOLOGY | 2006年 / 4卷 / 03期

关键词：

D O I：

10.1038/nrmicro1347

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Since the discovery of toxin-secreting killer yeasts more than 40 years ago, research into this phenomenon has provided insights into eukaryotic cell biology and virus-host-cell interactions. This review focuses on the most recent advances in our understanding of the basic biology of virus-carrying killer yeasts, in particular the toxin-encoding killer viruses, and the intracellular processing, maturation and toxicity of the viral protein toxins. The strategy of using eukaryotic viral toxins to effectively penetrate and eventually kill a eukaryotic target cell will be discussed, and the cellular mechanisms of self-defence and protective immunity will also be addressed.

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收藏

页码：212 / 221

页数：10

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