学术探索
学术期刊
新闻热点
数据分析
智能评审

A new class of biochemically degradable, stimulus-responsive triblock copolymer gelators

被引：217
作者：
Li, Chengming
Madsen, Jeppe
Armes, Steven P.
Lewis, Andrew L.
机构：
[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
[2] Biocompatibles Ltd, Farnham GU9 8QL, Surrey, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 21期
关键词：
biomimetic synthesis; copolymers; gels; micelles; peptide-induced degradation;
D O I：
10.1002/anie.200600324
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Graph Presented) To rub gel into the wound: A thermoresponsive ABA triblock copolymer gelator with A=N-isopropylacrylamide and B=2- (methacryloyloxy)ethyl phosphorylcholine has been synthesized by atom transfer radical polymerization by using a bifunctional disulfide-based initiator. This triblock copolymer forms free-standing peptide-degradable micellar gels under physiologically relevant conditions. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：3510 / 3513
页数：4
相关论文
共 39 条
[11]   VOLUME TRANSITION IN A GEL DRIVEN BY HYDROGEN-BONDING [J].
ILMAIN, F ;
TANAKA, T ;
KOKUFUTA, E .
NATURE, 1991, 349 (6308) :400-401
[12]  
Kurisawa M, 1998, MACROMOL CHEM PHYSIC, V199, P2613, DOI 10.1002/(SICI)1521-3935(19981101)199:11<2613::AID-MACP2613>3.0.CO
[13]  
2-W
[14]  
Kurisawa M, 1998, MACROMOL CHEM PHYSIC, V199, P705, DOI 10.1002/(SICI)1521-3935(19980401)199:4<705::AID-MACP705>3.3.CO
[15]  
2-0
[16]   Synthesis and characterization of biocompatible thermo-responsive gelators based on ABA triblock copolymers [J].
Li, CM ;
Tang, YQ ;
Armes, SP ;
Morris, CJ ;
Rose, SF ;
Lloyd, AW ;
Lewis, AL .
BIOMACROMOLECULES, 2005, 6 (02) :994-999
[17]   Synthesis and chemical degradation of branched vinyl polymers prepared via ATRP: Use of a cleavable disulfide-based branching agent [J].
Li, YT ;
Armes, SP .
MACROMOLECULES, 2005, 38 (20) :8155-8162
[18]   Biocompatibility and stability of disulfide-crosslinked hyaluronan films [J].
Liu, YC ;
Shu, XZ ;
Prestwich, GD .
BIOMATERIALS, 2005, 26 (23) :4737-4746
[19]   A photolabile hydrogel for guided three-dimensional cell growth and migration [J].
Luo, Y ;
Shoichet, MS .
NATURE MATERIALS, 2004, 3 (04) :249-253
[20]   Synthesis of biocompatible, stimuli-responsive, physical gels based on ABA triblock copolymers [J].
Ma, YH ;
Tang, YQ ;
Billingham, NC ;
Armes, SP ;
Lewis, AL .
BIOMACROMOLECULES, 2003, 4 (04) :864-868
1234