Highly Stereospecific Generation of Helical Chirality by Imprinting with Amino Acids: A Universal Sensor for Amino Acid Enantiopurity

被引：89

作者：

Kim, Hyunwoo ^{[3
]}

So, Soon Mog ^{[3
]}

Yen, Cindy Pai-Hui ^{[3
]}

Vinhato, Elisangela ^{[3
]}

Lough, Alan J. ^{[3
]}

Hong, Jong-In ^{[1
]}

Kim, Hae-Jo ^{[2
]}

Chin, Jik ^{[3
]}

机构：

[1] Seoul Natl Univ, Dept Chem, Seoul 151747, South Korea

[2] Kyonggi Univ, Dept Chem, Suwon 443760, South Korea

[3] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 45期

基金：

加拿大自然科学与工程研究理事会;

关键词：

amino acids; chirality; circular dichroism; helical structures;

D O I：

10.1002/anie.200803116

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Helical chirality can be imprinted onto a 2,2′-dihydroxybenzophenone derivative (see picture) in a highly stereospecific manner. A single amino acid combines with the receptor to form an imine with two internal hydrogen bonds. The azo group allows sensing of amino acid enantiopurity by circular dichroism spectroscopy. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8657 / 8660

页数：4

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