Cancer as a complex genetic trait: Tumor susceptibility in humans and mouse models
被引:108
作者:
Balmain, A
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机构:
Univ Calif San Francisco, Dept Biochem & Biophys, Ctr Comprehens Canc, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Biochem & Biophys, Ctr Comprehens Canc, San Francisco, CA 94143 USA
Balmain, A
[1
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机构:
[1] Univ Calif San Francisco, Dept Biochem & Biophys, Ctr Comprehens Canc, San Francisco, CA 94143 USA
Cancer directly affects at least one-third of the human population, but the inherited genetic determinants of cancer risk remain largely unknown. Mouse models of human cancer are helping us to understand this disease as a complex genetic trait and thus to identify the multiple genetic variant alleles involved in pathways that affect individual cancer susceptibility.