Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice

被引：210

作者：

Koike, H

Arguello, PA

Kvajo, M

Karayiorgou, M

Gogos, JA

机构：

[1] Rockefeller Univ, Human Neurogenet Lab, New York, NY 10021 USA

[2] Columbia Univ, Med Ctr, Dept Physiol & Cellular Biophys, New York, NY 10032 USA

[3] Columbia Univ, Med Ctr, Ctr Neurobiol & Behav, New York, NY 10032 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 10期

关键词：

animal model; gene mutation; psychiatric disorder; schizophrenia;

D O I：

10.1073/pnas.0511189103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Disrupted-in-Schizophrenia (DISC1) is a leading candidate schizophrenia susceptibility gene. Here, we describe a deletion variant in mDisc1 specific to the 129S6/SvEv strain that introduces a termination codon at exon 7, abolishes production of the full-length protein, and impairs working memory performance when transferred to the C57BL/6J genetic background. Our findings provide insights into how DISC1 variation contributes to schizophrenia susceptibility in humans and the behavioral divergence between 129S6/SvEv and C57BL/6J mouse strains and have implications for modeling psychiatric diseases in mice.

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收藏

页码：3693 / 3697

页数：5

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