TGF-β signaling:: positive and negative effects on tumorigenesis

被引：683

作者：

Wakefield, LM ^{[1
]}

Roberts, AB ^{[1
]}

机构：

[1] NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(01)00259-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

TGF-beta binding to the cell surface triggers activation of multiple signal transduction pathways that are connected in intricate ways with each other, and with other response networks involved in sensing cellular information input. Recent data indicate that changes in signal intensity and connectivity of these pathways may underlie the complex transition of the TGF-beta pathway from tumor suppressor to oncogene during tumorigenesis.

引用

页码：22 / 29

页数：8

共 63 条

[1] Inhibition of farnesyltransferase increases TGFβ type II receptor expression and enhances the responsiveness of human cancer cells to TGFβ
Adnane, J
Bizouarn, FA
Chen, Z
Ohkanda, J
Hamilton, AD
Munoz-Antonia, T
Sebti, SM
[J]. ONCOGENE, 2000, 19 (48) : 5525 - 5533
[2] Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration
Bakin, AV
Tomlinson, AK
Bhowmick, NA
Moses, HL
Arteaga, CL
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (47) : 36803 - 36810
[3] Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
Bhowmick, NA
Ghiassi, M
Bakin, A
Aakre, M
Lundquist, CA
Engel, ME
Arteaga, CL
Moses, HL
[J]. MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (01) : 27 - 36
[4] Different sensitivity of the transforming growth factor-ß cell cycle arrest pathway to c-Myc and IMDM-2
Blain, SW
Massagué, J
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (41) : 32066 - 32070
[5] Defective repression of c-myc in breast cancer cells:: A loss at the core of the transforming growth factor β growth arrest program
Chen, CR
Kang, YB
Massagué, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (03) : 992 - 999
[6] INACTIVATION OF THE TYPE-II RECEPTOR REVEALS 2 RECEPTOR PATHWAYS FOR THE DIVERSE TGF-BETA ACTIVITIES
CHEN, RH
EBNER, R
DERYNCK, R
[J]. SCIENCE, 1993, 260 (5112) : 1335 - 1338
[7] A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest
Claassen, GF
Hann, SR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (17) : 9498 - 9503
[8] The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
Comijn, J
Berx, G
Vermassen, P
Verschueren, K
van Grunsven, L
Bruyneel, E
Mareel, M
Huylebroeck, D
van Roy, F
[J]. MOLECULAR CELL, 2001, 7 (06) : 1267 - 1278
[9] Role of transforming growth factor-β signaling in cancer
de Caestecker, MP
Piek, E
Roberts, AB
[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (17): : 1388 - 1402
[10] TGF-β-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system
Ellenrieder, V
Hendler, SF
Ruhland, C
Boeck, W
Adler, G
Gress, TM
[J]. INTERNATIONAL JOURNAL OF CANCER, 2001, 93 (02) : 204 - 211

← 1 2 3 4 5 6 7 →