TGF-β signaling:: positive and negative effects on tumorigenesis

被引：683

作者：

Wakefield, LM ^{[1
]}

Roberts, AB ^{[1
]}

机构：

[1] NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(01)00259-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

TGF-beta binding to the cell surface triggers activation of multiple signal transduction pathways that are connected in intricate ways with each other, and with other response networks involved in sensing cellular information input. Recent data indicate that changes in signal intensity and connectivity of these pathways may underlie the complex transition of the TGF-beta pathway from tumor suppressor to oncogene during tumorigenesis.

引用

页码：22 / 29

页数：8

共 63 条

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