TGF-β signaling:: positive and negative effects on tumorigenesis

被引：683

作者：

Wakefield, LM ^{[1
]}

Roberts, AB ^{[1
]}

机构：

[1] NCI, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(01)00259-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

TGF-beta binding to the cell surface triggers activation of multiple signal transduction pathways that are connected in intricate ways with each other, and with other response networks involved in sensing cellular information input. Recent data indicate that changes in signal intensity and connectivity of these pathways may underlie the complex transition of the TGF-beta pathway from tumor suppressor to oncogene during tumorigenesis.

引用

页码：22 / 29

页数：8

共 63 条

[41] Ultraviolet irradiation blocks cellular responses to transforming growth factor-β by down-regulating its Type-II receptor and inducing Smad7
Quan, TH
He, TY
Voorhees, JJ
Fisher, GJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (28) : 26349 - 26356
[42] Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a smad-binding antagonist of transforming growth factor-β signaling
Rodriguez, C
Huang, LJS
Son, JK
McKee, A
Xiao, Z
Lodish, HF
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (32) : 30224 - 30230
[43] Oncogenic Ras represses transforming growth factor-β/Smad signaling by degrading tumor suppressor Smad4
Saha, D
Datta, PK
Beauchamp, RD
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (31) : 29531 - 29537
[44] Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-β1 in transformed keratinocytes
Santibáñez, JF
Iglesias, M
Frontelo, P
Martínez, J
Quintanilla, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 273 (02) : 521 - 527
[45] Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis
Schwarte-Waldhoff, I
Volpert, OV
Bouck, NP
Sipos, B
Hahn, SA
Klein-Scory, S
Lüttges, J
Klöppel, G
Graeven, U
Eilert-Micus, C
Hintelmann, A
Schmiegel, W
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (17) : 9624 - 9629
[46] TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b
Seoane, J
Pouponnot, C
Staller, P
Schader, M
Eilers, M
Massagué, J
[J]. NATURE CELL BIOLOGY, 2001, 3 (04) : 400 - 408
[47] Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor β-related signaling
Sirard, C
Kim, S
Mirtsos, C
Tadich, P
Hoodless, PA
Itié, A
Maxson, R
Wrana, JL
Mak, TW
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (03) : 2063 - 2070
[48] High-throughput drug screening of the DPC4 tumor-suppressor pathway in human pancreatic cancer cells
Sohn, TA
Su, GH
Ryu, B
Yeo, CJ
Kern, SE
[J]. ANNALS OF SURGERY, 2001, 233 (05) : 696 - 702
[49] Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor β growth inhibition in p16INK4A(-) human mammary epithelial cells
Stampfer, MR
Garbe, J
Levine, G
Lichtsteiner, S
Vasserot, AP
Yaswen, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (08) : 4498 - 4503
[50] Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency
Tang, BW
Böttinger, EP
Jakowlew, SB
Bagnall, KM
Mariano, J
Anver, MR
Letterio, JJ
Wakefield, LM
[J]. NATURE MEDICINE, 1998, 4 (07) : 802 - 807

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