Vpx association with mature core structures of HIV-2

被引：50

作者：

Kewalramani, VN

Emerman, M

机构：

[1] FRED HUTCHINSON CANC RES CTR,DIV MOLEC MED,SEATTLE,WA 98104

[2] FRED HUTCHINSON CANC RES CTR,DIV BASIC SCI,SEATTLE,WA 98104

[3] UNIV WASHINGTON,PROGRAM MOLEC & CELLULAR BIOL,SEATTLE,WA 98195

[4] UNIV WASHINGTON,DEPT MICROBIOL,SEATTLE,WA 98195

来源：

VIROLOGY | 1996年 / 218卷 / 01期

关键词：

D O I：

10.1006/viro.1996.0176

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vpx is a virion-incorporated protein encoded by HIV-2 and certain strains of SIV which is necessary for efficient infection of lymphocytes and macrophages. To determine the location of Vpx within the HIV-2 particle, core structures were obtained from mature HIV-2 virions. Analysis of purified cores reveal the presence of monomeric Vpx as well as a nondenaturable and nonreducible higher order Vpx complex. Characterization of the core-associated Vpx complex suggests it to be a Vpx homodimer, indicative of high concentrations of Vpx. The incorporation and concentration of Vpx in HIV-2 cores support the hypothesis that it functions within the viral preintegration complex. (C) 1996 Academic Press, Inc.

引用

页码：159 / 168

页数：10

共 47 条

[41] EVOLUTION OF THE PRIMATE LENTIVIRUSES - EVIDENCE FROM VPX AND VPR [J].