MicroRNAs in breast cancer initiation and progression

被引：78

作者：

Liu, Huiping ^{[1
]}

机构：

[1] Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2012年 / 69卷 / 21期

关键词：

MicroRNAs; Breast cancer stem cells; Metastasis; Therapy resistance; MiRNA biomarkers; MiRNA therapeutics; EPITHELIAL-MESENCHYMAL TRANSITION; MAMMARY-GLAND DEVELOPMENT; ACUTE MYELOID-LEUKEMIA; STEM-CELL PROPERTIES; DOWN-REGULATION; MIR-200; FAMILY; PROSPECTIVE IDENTIFICATION; MOLECULAR CHARACTERIZATION; TAMOXIFEN RESISTANCE; REPRESSORS ZEB1;

D O I：

10.1007/s00018-012-1128-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The emerging role of microRNAs (miRNAs) in the epigenetic regulation of many cellular processes has become recognized in both basic research and translational medicine as an important way that gene expression can be fine-tuned. Breast cancer is the most frequent cancer in women, with about one million new cases diagnosed each year worldwide. Starting with the early work of miRNA profiling, more effort has now been put on functions of miRNAs in normal mammary stem cells, breast cancer initiating cells and metastatic cells, and therapy-resistant cancer cells. Future translational studies may focus on identifying miRNA signatures as cancer biomarkers and developing miRNA-based targeted therapeutics.

引用

页码：3587 / 3599

页数：13

共 114 条

[1]

Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[2]

The functions of animal microRNAs [J].

Ambros, V .

NATURE, 2004, 431 (7006) :350-355

[3]

MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].

Asangani, I. A. ;

Rasheed, S. A. K. ;

Nikolova, D. A. ;

Leupold, J. H. ;

Colburn, N. H. ;

Post, S. ;

Allgayer, H. .

ONCOGENE, 2008, 27 (15) :2128-2136

[4]

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].

Bao, Shideng ;

Wu, Qiulian ;

McLendon, Roger E. ;

Hao, Yueling ;

Shi, Qing ;

Hjelmeland, Anita B. ;

Dewhirst, Mark W. ;

Bigner, Darell D. ;

Rich, Jeremy N. .

NATURE, 2006, 444 (7120) :756-760

[5]

MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[6]

MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype [J].

Blenkiron, Cherie ;

Goldstein, Leonard D. ;

Thorne, Natalie P. ;

Spiteri, Inmaculada ;

Chin, Suet-Feung ;

Dunning, Mark J. ;

Barbosa-Morais, Nuno L. ;

Teschendorff, Andrew E. ;

Green, Andrew R. ;

Ellis, Ian O. ;

Tavare, Simon ;

Caldas, Carlos ;

Miska, Eric A. .

GENOME BIOLOGY, 2007, 8 (10)

[7]

Bockhorn J, 2012, NAT COMMUN UNPUB

[8]

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].

Bonnet, D ;

Dick, JE .

NATURE MEDICINE, 1997, 3 (07) :730-737

[9]

let-7 microRNAs in development, stem cells and cancer [J].

Buessing, Ingo ;

Slack, Frank J. ;

Grosshans, Helge .

TRENDS IN MOLECULAR MEDICINE, 2008, 14 (09) :400-409

[10]

microRNA-Associated Progression Pathways and Potential Therapeutic Targets Identified by Integrated mRNA and microRNA Expression Profiling in Breast Cancer [J].

Buffa, Francesca M. ;

Camps, Carme ;

Winchester, Laura ;

Snell, Cameron E. ;

Gee, Harriet E. ;

Sheldon, Helen ;

Taylor, Marian ;

Harris, Adrian L. ;

Ragoussis, Jiannis .

CANCER RESEARCH, 2011, 71 (17) :5635-5645

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