MYC oncogene in myeloid neoplasias

被引：55

作者：

Dolores Delgado, M. ^{[1
]}

Albajar, Marta ^{[1
,2
,3
]}

Teresa Gomez-Casares, M. ^{[4
,5
]}

Batlle, Ana ^{[1
,2
,3
]}

Leon, Javier ^{[1
]}

机构：

[1] Univ Cantabria, Grp Transcript Control & Canc, Inst Biomed & Biotecnol Cantabria IBBTEC, Fac Med,Dept Biol Mol,CSIC,SODERCAN, Santander 39011, Spain

[2] Hosp Univ Marques de Valdecilla, Serv Hematol, Santander, Spain

[3] IFIMAV, Santander, Spain

[4] Hosp Dr Negrin, Serv Hematol, Las Palmas Gran Canaria, Spain

[5] Hosp Dr Negrin, Unidad Invest, Las Palmas Gran Canaria, Spain

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2013年 / 15卷 / 02期

关键词：

MYC; Myeloid neoplasia; Acute myeloid leukemia; Chronic myeloid leukemia; Myelodysplastic syndromes; CHRONIC MYELOGENOUS LEUKEMIA; DOUBLE MINUTE CHROMOSOMES; C-MYC; MYELODYSPLASTIC SYNDROME; DEREGULATED EXPRESSION; CELL-DIFFERENTIATION; HEMATOPOIETIC STEM; TRANSGENIC MICE; UP-REGULATION; GENE;

D O I：

10.1007/s12094-012-0926-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

MYC is a transcription factor that regulates many critical genes for cell proliferation, differentiation, and biomass accumulation. MYC is one of the most prevalent oncogenes found to be altered in human cancer, being deregulated in about 50 % of tumors. Although MYC deregulation has been more frequently associated to lymphoma and lymphoblastic leukemia than to myeloid malignancies, a body of evidence has been gathered showing that MYC plays a relevant role in malignancies derived from the myeloid compartment. The myeloid leukemogenic activity of MYC has been demonstrated in different murine models. Not surprisingly, MYC has been found to be amplified or/and deregulated in the three major types of myeloid neoplasms: acute myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms, including chronic myeloid leukemia. Here, we review the recent literature describing the involvement of MYC in myeloid tumors.

引用

页码：87 / 94

页数：8

共 98 条

[71]

EXPRESSION OF C-MYC UNDER THE CONTROL OF GATA-1 REGULATORY SEQUENCES CAUSES ERYTHROLEUKEMIA IN TRANSGENIC MICE [J].