Effect of exogenous interleukin-18 (IL-18) and IL-12 in the course of Brucella abortus 2308 infection in mice

被引：21

作者：

Pasquali, P

Adone, R

Gasbarre, LC

Pistoia, C

Ciuchini, F

机构：

[1] Ist Super Sanita, Lab Vet Med, I-00161 Rome, Italy

[2] ARS, Immunol & Dis Resistance Lab, Anim & Nat Resources Inst, USDA, Beltsville, MD 20705 USA

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2002年 / 9卷 / 02期

关键词：

D O I：

10.1128/CDLI.9.2.491-492.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study we demonstrated that combined inoculation of interieukin-12 (IL-12) and IL-18 reduced the number of bacteria in the spleens of mice infected with Brucella abortus 2308 and that the effect of the treatment was mediated by an increased capability of spleen cells to produce gamma interferon at the early phase of infection.

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收藏

页码：491 / 492

页数：2

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