Synthesis and characterization of captopril derivatives

被引：2

作者：

Li, He-ping ^{[1
]}

Zhang, Juan-juan ^{[1
]}

Qin, Long ^{[1
]}

Zhao, Ming-dong ^{[1
]}

机构：

[1] Changsha Univ Sci & Technol, Coll Chem & Biol Engn, Changsha 410004, Hunan, Peoples R China

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2013年 / 39卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Captopril; Amino acid methyl ester; Synthesis; Acylation; ANGIOTENSIN-CONVERTING ENZYME; PEPTIDES; AMINES; CHAIN;

D O I：

10.1007/s11164-012-0584-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To develop more potential angiotensin converting enzyme (ACE) inhibitors, a series of captopril (Cap) derivatives were synthesized, including Cap-glycine methyl ester, Cap-l-alanine methyl ester, Cap-l-aspartic acid dimethyl ester, Cap-l-lysine methyl ester, Cap-O-acylisourea, acetyl captopril, and benzoyl captopril. The resulting products were characterized by IR and UV-visible spectroscopy and MS, which showed the desired products were successfully synthesized. This could serve as a guide for rational design of highly potent ACE inhibitors.

引用

页码：621 / 629

页数：9

共 21 条

[11] Synthesis and characterization of ramose tetralactosyl-lysyl-chitosan-5-fluorouracil and its in vitro release [J].

Li, He-ping ;

Qin, Long ;

Wang, Zhou-dong ;

Li, Shan .

RESEARCH ON CHEMICAL INTERMEDIATES, 2012, 38 (07) :1421-1429

[12] A convenient synthesis of amino acid methyl esters [J].

Li, Jiabo ;

Sha, Yaowu .

MOLECULES, 2008, 13 (05) :1111-1119

[13]

LOSCALZO J, 1989, J PHARMACOL EXP THER, V249, P726

[14]

Pher G.A., 1997, J ORG CHEM, V62, P7364

[15] Evaluation of possible intramolecular [4+2] cycloaddition routes for assembling the central tetracyclic core of the potent marine antfinflammatory agent mangicol A [J].

Pichlmair, Stefan ;

de Lera Ruiz, Manuel ;

Basu, Kallol ;

Paquette, Leo A. .

TETRAHEDRON, 2006, 62 (22) :5178-5194

[16] Hepatoprotective activity of angiotensin-converting enzyme (ACE) inhibitors, captopril and enalapril, against paraquat toxicity [J].

Pourahmad, Jalal ;

Hosseini, Mir-Jamal ;

Bakan, Soudeh ;

Ghazi-Khansari, Mahmoud .

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 2011, 99 (01) :105-110

[17]

Prabhu M, 2005, Kathmandu Univ Med J (KUMJ), V3, P296

[18]

Sacha C., 2009, J APPL BIOMED, V7, P123

[19] Whey proteins as source of dipeptidyl dipeptidase IV (dipeptidyl peptidase-4) inhibitors [J].

Tulipano, Giovanni ;

Sibilia, Valeria ;

Caroli, Anna Maria ;

Cocchi, Daniela .

PEPTIDES, 2011, 32 (04) :835-838

[20] Solubility of Captopril in 2-Propanol, Acetone, Acetonitrile, Methyl Acetate, Ethyl Acetate, and Butyl Acetate [J].

Wang, Jingkang ;

Gao, Li ;

Liu, Yan .

JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2010, 55 (02) :966-967

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